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Protective VEGF Inhibition for Isotoxic Dose Escalation in Glioblastoma — PRIDE  

Glioblastoma Clinical Trial

Official title:
A Phase IIa, Open-label, Multicenter Study of Radiochemotherapy With Isotoxic Dose Escalation and Protective VEGF Inhibition Using Bevacizumab in the Treatment of Patients With First Diagnosis of IDH Wild-type, MGMT Unmethylated Glioblastoma

Clinical Trial Summary

Glioblastoma is the most aggressive brain tumor and often recurs locally despite intensive treatment. Standard chemoradiotherapy with 60 Gy may not be sufficient to control the tumor, and dose escalation seems to be warranted, but causes more toxicity. To address this, the multicentric PRIDE trial employs two cycles of bevacizumab to achieve dose escalation isotoxically. The goal is improved survival without significantly increasing side effects. The study uses a simultaneous integrated boost with a total dose of 75 Gy in 2.5 Gy per fraction.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05871021
Study type Interventional
Source Ludwig-Maximilians - University of Munich
Contact Ulrike Plugradt
Phone 004989440074770
Email Ulrike.Pflugradt@med.uni-muenchen.de
Status Recruiting
Phase Phase 2
Start date April 10, 2024
Completion date July 10, 2027
View Details
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