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Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs — 2253  

Glioblastoma Clinical Trial

Official title:
Grafts of Patient-derived Glioblastoma Stem Cells Onto Autologous Brain Organoids. A Precision Medicine Model for Testing Drugs Against Tumor Invasion

Clinical Trial Summary

In patients operated for glioblastoma, glioma stem-like cell lines will be obtained from tumor tissue, and IPSCs from skin fibroblasts or PBMCs. Brain organoids will be generated from IPSCs and co-cultured with IPSCs to study brain invasion and ciliogenesis. 3D genome architecture of glioma stem-like cells will be investigated. Gene modulation and pharmacologic strategies to inhibit invasion and restore ciliogenesis will be explored.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05772741
Study type Interventional
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Roberto Pallini, MD, PhD
Phone +39 06 3015 5414
Email roberto.pallini@unicatt.it
Status Recruiting
Phase N/A
Start date December 3, 2018
Completion date December 31, 2023
View Details
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