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NCT05759195 Clinical Trial

Biomolecular Analysis for Predicting Response to Regorafenib

Glioblastoma Clinical Trial

— RegoRec  

Official title:
Tumor Biomolecular Analysis for Defining Predictive Factors for Response to Regorafenib in Recurrent Glioblastoma

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05759195
Other study ID # 3458
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date January 7, 2021
Est. completion date December 31, 2024

Study information
Verified date February 2023
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Q. Giorgio D'Alessandris, MD
Phone +39 06 30155414
Email quintinogiorgio.dalessandris@policlinicogemelli.it
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The study envisages NGS analysis on tumor tissue from patients treated with regorafenib for recurrent glioblastoma as per standard care, with the aim to identify predictive biomarkers for response.

Recruitment information / eligibility
Status Recruiting
Enrollment 55
Est. completion date December 31, 2024
Est. primary completion date June 30, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. recurrent glioblastoma after surgery and chemoradiation with temozolomide; 2. indication to treatment with regorafenib per standard of care; 3. written informed consent. Exclusion Criteria: None.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Biomolecular tumor analysis
NGS analysis, other molecular analyses on FFPE tumor tissue

Locations
Country Name City State
Italy Fondazione Policlinico Universitario A. Gemelli IRCCS Rome

Sponsors (1)
Lead Sponsor Collaborator
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Overall survival through study completion, an average of 3 years
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