CARv3-TEAM-E T Cells in Glioblastoma

Status Recruiting

Clinical Trial Summary

The goal of this research study is to determine the best dose of CARv3-TEAM-E T Cells for treating participants with glioblastoma. The name of the treatment intervention used in this research study is: -CARv3-TEAM-E T Cells (or Autologous T lymphocytes).

Clinical Trial Description

This is a non-randomized, open label, single site Phase 1 study to define the appropriate dose of CARv3-TEAM-E and evaluate its safety for the treatment of recurrent or newly diagnosed glioblastoma. The U.S. Food and Drug Administration (FDA) has not approved CARv3-TEAM-E T Cells as a treatment for any disease. This is the first time that CARv3-TEAM-E T Cells will be given to humans. CARv3-TEAM-E T Cells are made from a person's own collected immune cells (T-Cells) that are genetically changed and then delivered back into the body to try to kill their cancerous cells. The research study procedures include screening for eligibility, study treatment, including evaluations and follow up visits, blood collections, echocardiograms, and radiologic imaging of tumors. It is expected participants will receive treatment over a period of approximately 6 weeks with a period of short-term and then long term follow-up of up to 15 years. It is expected that about 21 people will take part in this research study. This research study has received funding through an internal grant program. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05660369
Study type	Interventional
Source	Massachusetts General Hospital
Contact	William Curry, MD
Phone	617-724-6226
Email	carteamingbm@mgb.org
Status	Recruiting
Phase	Phase 1
Start date	March 22, 2023
Completion date	June 1, 2026

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