Personalized Trial in ctDNA-level-relapse Glioblastoma

Status Not yet recruiting

Clinical Trial Summary

Tumor in situ fluid (TISF) refers to the fluid within the surgical cavity of patients with glioblastoma. Postoperative serial TISF is collected for circulating tumor DNA (ctDNA) analysis and identifying ctDNA-level relapse driven by one or a set of specific genomic alterations before overt imaging recurrence of the tumor. This single-arm open-label prospective pilot feasibility trial recruiting 20 adult patients with ctDNA-level-relapse glioblastoma who are assigned to receive the personalized study treatment based on the genetic profile of their serial TISF ctDNA. It will be aimed to test whether the personalized intervention can prolong the progression-free and overall survival and the feasibility of conducting a full-scale trial.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Glioblastoma

Clinical Trial Details

NCT number	NCT05539339
Study type	Interventional
Source	Henan Provincial People's Hospital
Contact	Xingyao Bu, MD, PhD
Phone	+86037165580295
Email	xingyaob@zzu.edu.cn
Status	Not yet recruiting
Phase	N/A
Start date	December 1, 2022
Completion date	June 1, 2025

View Details

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