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Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma

Glioblastoma Clinical Trial

Official title:
Randomized Phase III Study of Conventional Versus Hypofractionated Radiotherapy Combined With Temozolomide in Elderly Glioblastoma Patients

Clinical Trial Summary

In newly diagnosed glioblastoma patients aged 70 years or older who are suitable for concurrent temozolomide, the optimal dose of radiation therapy is controversial . The purpose of this study is to compare conventional radiotherapy of 60 Gy (6 weeks) versus hypofractionated radiotherapy of 40 Gy (3 weeks) in terms of overall survival as the primary endpoint along with progression-free survival, toxicity, quality of life, and prognostic biomarkers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05439278
Study type Interventional
Source Seoul National University Boramae Hospital
Contact Chan Woo Wee, MD, PhD
Phone +82-2-870-1695
Email wcw0108@snu.ac.kr
Status Not yet recruiting
Phase Phase 3
Start date August 1, 2022
Completion date July 31, 2027
View Details
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