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Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma (IMPACT) — IMPACT  

Glioblastoma Clinical Trial

Official title:
Phase I Study -To Assess Safety and Feasibility of IL-8 Receptor Modified Patient-derived Activated CD70 CAR T Cell Therapy in CD70+ Adult GBM

Clinical Trial Summary

This is a phase I study to assess the safety and feasibility of IL-8 receptor modified patient-derived activated CD70 CAR T cell therapy in CD70+ adult glioblastoma.

Clinical Trial Description

Newly diagnosed CD70 positive adult GBM patients who have undergone surgery for maximal debulking will be enrolled in this 3+3 design dose-escalation clinical trial and undergo peripheral venipuncture for collection of PBMCs for generation of investigational 8R-70CAR T Cell vaccine. Patients will then undergo standard of care chemoradiation. Immunotherapy will begin 2 weeks (-7/+4 days) after completion of radiation. One single dose of 8R-70CAR T cells will be administered IV. The dose will depend on the enrolling cohort. Dose escalation will follow the traditional 3+3 design. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05353530
Study type Interventional
Source University of Florida
Contact Phuong Deleyrolle, RN
Phone 352-273-9000
Email phuong.deleyrolle@neurosurgery.ufl.edu
Status Recruiting
Phase Phase 1
Start date July 25, 2023
Completion date December 2042
View Details
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