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Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression — GLIOASTRA  

Glioblastoma Clinical Trial

Official title:
A Study to Evaluate the Safety and Efficacy of Different Administration Sequences of L19TNF in Combination With Lomustine in Patients With Glioblastoma at First Progression

Clinical Trial Summary

Open label phase I study in subjects with glioblastoma at first progression to explore two different administration schedules of lomustine for the combination with L19TNF (ARM 1 and ARM 2). Patients will be assigned in an alternating fashion to ARM 1 "Fractionating lomustine" or ARM 2 "Priming with L19TNF" as long as both treatment arms are open. Should one treatment arm be stopped as more or equal to two dose limiting toxicities occur in this treatment arm, then all remaining patients will be assigned to the treatment arm that is still open until also this treatment arm will be stopped.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05304663
Study type Interventional
Source Philogen S.p.A.
Contact
Status Withdrawn
Phase Phase 1
Start date June 1, 2022
Completion date December 31, 2024
View Details
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