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NCT04846257 Clinical Trial

Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Glioblastoma Clinical Trial

Official title:
Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04846257
Other study ID # DCE_MRI_GBM
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date February 1, 2021

Study information
Verified date April 2021
Source Egyptian Medical Syndicate
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Radiological Markers of vascularity as wash-in rate, washout rate, and capillary time to peak in different single tumour regions were extracted for all glioblastoma patients before being surgically resected from preoperative DCE-MRI. Tissue samples were obtained from different intratumoral regions and peritumoral oedema and evaluated for the vascular endothelial growth factor (VEGF)

Recruitment information / eligibility
Status Completed
Enrollment 260
Est. completion date February 1, 2021
Est. primary completion date January 1, 2021
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients with newly diagnosed glioblastoma with a maximum diameter from 3-5 cm as a single lesion identified by MRI. - The lesions should be surgically resected at the time of the presentation. Exclusion Criteria: N/A

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Dynamic contrast-enhanced MRI
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the acquisition of sequential images during the passage of a contrast agent within a tissue of interest.

Locations
Country Name City State
Egypt Department of Neurosurgery, Cairo University Faculty of Medicine Cairo

Sponsors (1)
Lead Sponsor Collaborator
Egyptian Medical Syndicate

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Recurrence of tumor 2018-2021
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