A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

Status Terminated

Clinical Trial Summary

This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and may have efficacy in brain tumors with the BRAF V600E mutation.

Clinical Trial Description

The primary goal of this study is to establish concentrations of dabrafenib and trametinib in enhancing brain tissue and cerebrospinal fluid from people with BRAF-V600E mutant recurrent gliomas who undergo tumor resection. The exploratory goals are to measure the amount of ERK signaling pathway activity, to identify mechanisms of resistance to these drugs, and evaluate feasibility of measuring tumor DNA in cerebrospinal fluid. People (adults or children) with brain tumors who are already taking dabrafenib and / or trametinib and are in need of a surgical resection are potentially eligible. On the day of surgery, blood, cerebrospinal fluid, and tumor tissue will be collected for research purposes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03593993
Study type	Observational
Source	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Contact
Status	Terminated
Phase
Start date	May 19, 2018
Completion date	July 7, 2023

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