Glioblastoma Clinical Trial
Official title:
Study of Prognostic Biomarkers of Survival at 6 Months for Patients Treated With Bevacizumab Glioblastomas in First Relapse After Failure of Radiochemotherapy
No predictive factors are known for the response to the bevacizumab anti-angiogenic molecule
(Avastin) given in the event of relapse of glioblastoma (GBM) following radiochemotherapy.
Classical MRI with gadolinium injection and perfusion is not sufficient to predict survival
and response or duration. We propose to evaluate the prognostic interest for 6-month survival
of spectroscopic biomarkers of proliferation, glial reaction, infiltration and glutaminergic
metabolism or glycolytic metabolism recorded at 7 and 28 days of application of the
treatment.
These biomarkers are based on the increase of an index combining choline / Creatine (Cho /
Cr), Glx / Cr (Glutamine and glutamate / Creatine), NAA / Cr (N acetyl aspartate / Creatine)
and lactate / Cr ratios. The long-term objective is to predict the survival of these relapsed
GBM patients at an early stage and to identify responder patients who would benefit from this
expensive molecule and avoid using it in non-responding patients
n/a
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