Glioblastoma Clinical Trial
Official title:
Randomized Phase II/III Trial of Radiotherapy Plus Concomitant and Adjuvant Temozolomide With or Without Hydroxychloroquine, Rapamycin for Newly Diagnosed Glioblastoma
This is a multi-center, phase II/III, open-label, randomized, parallel and standard chemoradiation-controlled study where eligible subjects will be randomized at 1:1 ratio to receive control treatment or study treatment. The primary objective of this trial is to evaluate the effect of add-on JP001 to standard chemoradiation in increasing overall survival (OS) on newly diagnosed glioblastoma (GBM) patients.
Status | Recruiting |
Enrollment | 288 |
Est. completion date | April 2025 |
Est. primary completion date | April 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 80 Years |
Eligibility | Inclusion Criteria: 1. Subjects with histologically proven newly diagnosed case of GBM (WHO grade IV) and treatment-naive (chemotherapy and radiotherapy) for GBM. Diagnosis must be made by stereotactic biopsy or surgical excision, either partial or complete within 3 months prior to Visit 1. 2. Subject's RPA class is class III, IV or V. 3. Subjects with stereotactic biopsy or brain surgery must be suited for or will be scheduled for CCRT followed by Temozolomide treatment, the standard treatment recommended by institutes and fulfilled the reimbursement guideline of National Health Insurance Administration. 4. Subjects must have recovered from the effects of surgery, post-operative infection, and other complications prior to Visit 1. Study treatment must be performed > 3 weeks and = 8 weeks after craniotomy. Ventricular fluid reservoir or Ventriculo-Peritoneal shunting tube is allowed to keep. 5. A diagnostic contrast-enhanced MRI of the brain must be performed postoperatively within 28 days prior to Visit 2 (Day 1). 6. ECOG performance status = 3 at Visit 1. 7. Age from 20 to 80 years old at Visit 1. 8. Life expectation = 12 weeks at Visit 1. 9. CBC/differential obtained at Visit 1, with adequate bone marrow function defined as follows: 1. Absolute neutrophil count (ANC) = 1,500 cells/mm3 (1.5 x 109/L) or white blood cell (WBC) = 3,000 cells/mm3 (3 x 109/L). 2. Platelets count = 100,000 cells/mm3 (100 x 109/L). 3. Hemoglobin (Hgb or Hb) = 10.0 g/dL (100 g/L) (Note: The use of transfusion or other intervention to achieve Hemoglobin = 10.0 g/dL (100 g/L) is acceptable). 10. Adequate renal function, as defined below: a. Creatinine = 1.5 times upper laboratory limit at Visit 1. 11. Adequate hepatic function, as defined below: 1. Total Bilirubin = 2.0 mg/dL (34.20 umol/L) at Visit 1. 2. ALT = 3 times upper laboratory limit at Visit 1. 3. AST = 3 times upper laboratory limit at Visit 1. 12. Subjects is able to understand and willing to comply with the study procedures and has signed the informed consent form (ICF). Exclusion Criteria: 1. Other invasive malignancy. However, subject with other invasive malignancy that have been disease-free more than or equal to 10 years and deemed no need for anti-cancer treatments can be recruited. Subjects with noninvasive malignancy, including carcinoma in situ of the breast, non-melanomatous skin cancer and cervix carcinoma in situ can be recruited if disease-free and treatment free more than or equal to 3 years. 2. Metastases detected beyond the cranial vault. 3. Subjects with the following history: 1. Brain irradiation or Temozolomide usage. 2. Macular degeneration or retinopathy. 3. Renal transplantation. 4. Subjects are currently receiving any anti-rejection medicine or Hydroxychloroquine sulfate for rheumatoid arthritis. 5. Subjects with severe and active co-morbidity, defined as follows: 1. Clinical active kidney, liver, lung or cardiac disease. 2. Acute bacterial or fungal infection requiring intravenous antibiotics at Visit 1 and acquired immune deficiency syndrome (AIDS). 3. Any active infection or uncontrolled infection at Visit 1. 4. Abnormal CXR finding with risks of infection and interstitial lung disease/pneumonitis. 6. Pregnant or lactating women, due to possible adverse effects on the developing fetus or infant from study drug. 7. Mean QTc > 500 msec (with Bazett's correction), history of familial long QT syndrome or other significant ECG abnormality noted at Visit 1. 8. Known hypersensitivity reactions to Temozolomide, dacarbazine (DTIC), hydroxychloroquine, 4-aminoquinoline, rapamune, sirolimus, rapamycin, or their analogs. 9. Women of child-bearing potential or men who are able to father a child unwilling to use a. medically acceptable method of contraception during the trial. 10. Subjects participated in another investigational agent study in the past 30 days or are planning to do so during the study period. 11. Subjects are considered ineligible for the study as judged by the investigator. 12. Subjects with positive HBsAg or positive anti-HCV. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Taipei Veterans General Hospital | Taipei City | |
Taiwan | Tri-Service General Hospital | Taipei City |
Lead Sponsor | Collaborator |
---|---|
Johnpro Biotech, Inc. |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall survival time. | All subjects will be followed until study end (the date of last subject last visit; the last subject need to be followed at least 30 months) or death, whichever comes first; OS defined as the time from the date of Randomization to the date of death or last follow-up. | 120 weeks | |
Secondary | Progression-free survival time | All subjects will be followed until study end or disease progression confirmed, whichever comes first; PFS defined as the time from the date of Randomization to the date of disease progression, death or last follow-up. | 120 weeks | |
Secondary | OS rate at 1 year. | OS defined as the time from the date of Randomization to the date of death or last follow-up. | 1 year | |
Secondary | PFS rate at 1 year. | PFS defined as the time from the date of Randomization to the date of disease progression, death or last follow-up. | 1 year | |
Secondary | The time and rate of OS in different RPA class. | 120 weeks | ||
Secondary | The time and rate of PFS in different RPA class. | 120 weeks | ||
Secondary | Objective response rate. | Defined as the proportion of subjects who were confirmed completed response or partial response determined by RANO criteria. | 120 weeks | |
Secondary | Changes in score of EORTC QLQ-C30 | 120 weeks | ||
Secondary | Changes in score of EORTC QLQ-BN20. | 120 weeks | ||
Secondary | Changes in grade of ECOG performance status. | 120 weeks |
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