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NCT02887417 Clinical Trial

Glioblastoma Platelet Activation Study

Glioblastoma Clinical Trial

— GPAS  

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02887417
Other study ID # Glioma-HGW
Secondary ID
Status Completed
Phase N/A
First received August 18, 2016
Last updated July 31, 2017
Start date January 2016
Est. completion date December 2016

Study information
Verified date July 2017
Source University Medicine Greifswald
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.

Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.

Description:

Glioblastoma face an increased risk of venous or arterial thromboembolism. Furthermore, the most frequent immune cells in glioblastoma are tumor associated macrophages, which find theirself in an anti-inflammatory (M2) phenotype.

Increased conjugates between circulating platelets and monocytes reflect an pro-inflammatory status.

Recruitment information / eligibility
Status Completed
Enrollment 21
Est. completion date December 2016
Est. primary completion date October 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- MR-morphological suspicion for glioblastoma

- informed consent

Exclusion Criteria:

- no informed consent

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Germany Department of Neurosurgery Greifswald

Sponsors (1)
Lead Sponsor Collaborator
University Medicine Greifswald

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Mean P-selectine expression in all platelets 01/ 2016 - 10/ 2016
Primary Mean CD63 expression in all platelets 01/ 2016 - 10/ 2016
Primary Mean CD40 Expression in all platelets 01/ 2016 - 10/ 2016
Primary Mean platelet-monocyte-conjugate formation in the monocyte population 01/ 2016 - 10/ 2016
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