Disulfiram in Recurrent Glioblastoma

Status Completed

Clinical Trial Summary

Clinical Trial Description

Disulfiram (Antabuse®) is a well-tolerated, cheap, generic drug that has been in use since the 1950s to treat alcoholism. There is now an increasing amount of independent preclinical data to support disulfiram as an anticancer agent. The potency of disulfiram as an anticancer agent seems strengthened by copper. There is now anecdotal clinical evidence of disulfiram as an anticancer agent. So far no clinical studies have been published in glioma patients, but two small, uncontrolled studies are planned according to clinicaltrials.gov. with search 1st November 2015. The investigators aim to investigate disulfiram and copper-supplement as add-on treatment in glioblastoma patients with recurrence receiving alkylating chemotherapy. The study will be performed as a multicenter RCT including patients in Norway and Sweden. This will serve as a proof-of concept study. The primary end-point is survival at 6 months ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02678975
Study type	Interventional
Source	Sahlgrenska University Hospital, Sweden
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	January 2017
Completion date	January 15, 2021

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See also
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