Glioblastoma Clinical Trial
Official title:
Phase IIb Trial Evaluations Of The Effectiveness Of Treatment Glioblastoma / Gliosarcoma Through The Suppression Of The PI3K/Akt Pathway In Compared With MK-3475 (Pembrolizumab)
It is known that after application of MK-3475 activated PD -1 negatively regulates the
activation of T cells through suppression of the path of PI3K / Akt.
This study will identify the effectiveness of oral inhibitors of PI3K / Akt pathway in
comparison with MK-3475 (pembrolizumab).
A humanized monoclonal IgG4 antibody directed against human cell surface receptor PD-1
(programmed death-1 or programmed cell death-1) with potential immunopotentiating activity.
Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed
on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its
ligands, which results in the activation of T-cell-mediated immune responses against tumor
cells. The ligands for PD-1 include PD-L1, which is expressed on antigen presenting cells
(APCs) and overexpressed on certain cancer cells, and PD-L2, which is primarily expressed on
APCs. Activated PD-1 negatively regulates T-cell activation through the suppression of the
PI3K/Akt pathway.
This study will identify the effectiveness of oral inhibitors of PI3K / Akt pathway in
comparison with MK-3475 (pembrolizumab).
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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