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Clinical Trial Summary

The purpose of this research study is to test the safety, tolerability, and effectiveness of the combination of three drugs, sorafenib (Nexavar®), valproic acid (Depakote®), and sildenafil (Viagra®), when used to treat high-grade glioma, a type of brain tumor.


Clinical Trial Description

The study is a single-center, open-label phase 2 study, with an early stopping rule in place for safety. The trial will include patients with recurrent or progressive high-grade glioma. The trial will be conducted in an adaptive design, with a Simon's mini-max 2-stage design incorporating an interim analysis for efficacy ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01817751
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Active, not recruiting
Phase Phase 2
Start date April 11, 2013
Completion date October 30, 2027

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