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Repurposing Chlorpromazine in the Treatment of Glioblastoma — RACTAC  

Glioblastoma Multiforme Clinical Trial

Official title:
Repurposing the Antipsychotic Drug Chlorpromazine as a Therapeutic Agent in the Combined Treatment of Newly Diagnosed Glioblastoma Multiforme

Clinical Trial Summary

This study evaluates the addition of chlorpromazine to the first-line therapeutic protocol, i.e. maximal well-tolerated surgical resection followed by radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide, in newly diagnosed glioblastoma multiforme patients carrying a hypo-methylated O6-methylguanine-DNA-methyltransferase (MGMT) gene

Clinical Trial Description

Chlorpromazine (CPZ, Largactil, Thorazine) is a potent antagonist of the dopamine receptor D2 (DRD2) and has been effectively and safely employed for over half a century in the treatment of psychiatric disorders. CPZ displays a series of remarkable bio-molecular effects in cancer cells, as inhibition of cell growth, nuclear aberrations, inhibition of the phosphoinositide 3-kinase/mammilian target of rapamycin (PI3K/mTOR) axis, induction of cytotoxic autophagy, inhibition of glutamate and DRD2 receptors. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04224441
Study type Interventional
Source Regina Elena Cancer Institute
Contact Andrea Pace, MD
Phone +39 06 52666975
Email andrea.pace@ifo.gov.it
Status Recruiting
Phase Phase 2
Start date December 15, 2019
Completion date December 15, 2022
View Details
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