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Simultaneous Integrated Boost in Malignant Glioma Patients Treated With Chemoradiation

Glioblastoma Multiforme Clinical Trial

Official title:
Evaluation the Prognostic Significance of High Radiation Dose in Malignant Glioma Patients Treated With Chemoradiation

Clinical Trial Summary

Simultaneous integrated boost (SIB), a field-in-field escalation technique, has been introduced to deliver higher radiation dose to the certain part of target with the same fractionation scheme. The aim of this study was to investigate the value of chemoradiation (CCRT) using SIB in glioblastoma and the correlation with surgical extent.

Clinical Trial Description

The SIB technique provides the higher radiobiological effect with the same fractionation scheme, i.e. 69 Gy over 6 weeks, which might increase the loco-regional control. Besides, the co-registration with magnetic resonance imaging (MRI) strengthens the precision of target delineation as well as higher possibility to spare adjacent normal brain tissue.

In this protocol, the newly diagnosed, primary glioblastoma patients received SIB 69 Gy/30 fractions to preoperative tumor bed and surgical cavity, while 60 Gy/30 fractions were covering preoperatively edematous area. To determine the status of surgical extent, postoperative CT scan and MRI was acquired within 72 hours and at 4th week after surgery. During the period of chemoradiation, acute neurotoxicity and hematological toxicity was assessed as well. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03225300
Study type Interventional
Source Taichung Veterans General Hospital
Contact
Status Recruiting
Phase N/A
Start date January 1, 2005
Completion date December 31, 2017
View Details
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