Glioblastoma Multiforme Clinical Trial
Official title:
A Phase I-II Study of Allogeneic CMV Specific Cytotoxic T Lymphocytes (CTL) for Patients With Refractory Glioblastoma Multiforme (GBM)
The primary purpose of this study is to determine the safety and efficacy of the infusion of partially matched, allogeneic, CMV specific cytotoxic T cells (CTL) for patients with GBM that have failed primary therapy.
Tumor specimens of consenting patients will be tested by immunohistochemistry (IHC) for the
presence of IE-1 and/or pp65. Subjects whose tumors test positive for either or both CMV
antigens will be consented for the treatment phase which will include a regimen of
fludarabine and cyclophosphamide daily for two days, cyclophosphamide only for a third day,
followed by one day of rest prior to the day of CTL infusion.
This trial intended to be a Phase 1/2 trial, but it never progressed to Phase 2 before
termination.
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|---|---|---|---|
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