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Clinical Trial Summary

This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma who have recently had surgery to remove most or all of the brain tumor (resected). Chemotherapy drugs, such as 6-benzylguanine, temozolomide, and carmustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing. Placing P140K MGMT, a gene that has been created in the laboratory into bone marrow making the bone more resistant to chemotherapy, allowing intra-patient dose escalation which kills more tumor cells while allowing bone marrow to survive.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05052957
Study type Interventional
Source Case Comprehensive Cancer Center
Contact Melissa Bratley, RN
Phone 1-800-641-2422
Email CTUreferral@uhhospitals.org
Status Recruiting
Phase Phase 2
Start date January 20, 2023
Completion date December 1, 2024

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