Clinical Trials Logo

Clinical Trial Summary

The objective of the study is to collect and assess adaptive optics (AO) retinal images from human subjects in support of projects to demonstrate, advance, and enhance clinical use of AO technology.


Clinical Trial Description

Objective: The objective of the study is to collect and assess adaptive optics (AO) retinal images from human subjects in support of projects to demonstrate, advance, and enhance clinical use of AO technology. Study Population: Fifty (50) healthy volunteers without eye disease and thirty (30) subjects with primary open angle glaucoma (POAG) will be enrolled. Design: This is an interventional study protocol where participants will be imaged with investigational multimodal AO retinal imaging systems that include optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) channels. High resolution OCT and SLO videos will be collected while the instruments automatically detect and correct for image distortion caused by ocular aberrations. In general, videos of different retinal structures will be acquired from several retinal locations using various imaging modes. Outcome Measures: The primary outcomes for this protocol are qualitative and quantitative assessment of the AO images and investigation of the cellular morphological and physiological changes due to glaucoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05370287
Study type Interventional
Source Food and Drug Administration (FDA)
Contact Daniel X Hammer, Ph.D.
Phone 301-796-9320
Email daniel.hammer@fda.hhs.gov
Status Recruiting
Phase N/A
Start date January 22, 2018
Completion date September 30, 2026

See also
  Status Clinical Trial Phase
Recruiting NCT02679482 - Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma N/A
Recruiting NCT05999006 - Safety and Feasibility of the ELIOS System in POAG Patients N/A
Completed NCT05181046 - Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Timolol Maleate in Glaucoma Patients N/A
Completed NCT01999348 - A Study of GANFORT® UD in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) in a Medical Setting
Completed NCT04149899 - Safety and IOP-Lowering Effects of WB007 Phase 1/Phase 2
Not yet recruiting NCT04007276 - The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients Phase 4
Completed NCT01814761 - A Study of Bimatoprost 0.01% in the Clinical Setting Phase 4
Active, not recruiting NCT04899063 - Excimer Laser Trabeculostomy Glaucoma Treatment Study N/A
Completed NCT05474716 - The Effect of Topical Brimonidine on the Ocular Hemodynamics in Patients of POAG Using OCTA Phase 4
Recruiting NCT03067415 - Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily Phase 2
Not yet recruiting NCT06053307 - Treating Psychosocial Distress in Glaucoma N/A
Completed NCT02796560 - Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension Phase 4
Terminated NCT02858284 - Evaluation of Safety and Efficacy of TUG (Therapeutic Ultrasound for Glaucoma) in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension N/A
Not yet recruiting NCT05673954 - Glaucoma Assessment Via Reading Ability
Active, not recruiting NCT03318510 - LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma N/A
Active, not recruiting NCT03151577 - Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent N/A
Completed NCT04465864 - Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert Phase 4
Recruiting NCT03675412 - Caffeine Consumption in Glaucoma Patients and Healthy Subjects N/A
Completed NCT01833741 - A Study of LUMIGAN® RC in the Clinical Setting Phase 4
Completed NCT03800589 - Assessment of Effectiveness Ex-Press Surgery Modification N/A