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NCT05498103 Clinical Trial

Use of Methazolamide to Lower Intraocular Pressure

Glaucoma, Open-Angle Clinical Trial

Official title:
Use of Methazolamide to Lower Intraocular Pressure

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05498103
Other study ID # 22-0721
Secondary ID
Status Active, not recruiting
Phase Phase 4
First received
Last updated
Start date February 17, 2023
Est. completion date December 2024

Study information
Verified date February 2024
Source University of Colorado, Denver
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 30
Est. completion date December 2024
Est. primary completion date September 14, 2023
Accepts healthy volunteers No
Gender All
Age group 50 Years to 90 Years
Eligibility Inclusion Criteria: - Males and females between 50 and 90 years old - Current diagnosis of open angle glaucoma (OAG) in both eyes - Ability to read and write in English Exclusion Criteria: - Glaucoma other than OAG - Severe or end-stage glaucoma (cup to disc ratio >0.8 or Mean Deviation on Visual Field worse than -12) - Pregnant or breast-feeding women

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Methazolamide 25 MG
25 mg tablets
• Methazolamide 50 MG
50 mg tablets

Locations
Country Name City State
United States Sue Anschutz-Rodgers Eye Center Aurora Colorado

Sponsors (1)
Lead Sponsor Collaborator
University of Colorado, Denver

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Percent IOP change at each follow-up Visit IOP measure is measured using Goldmann Tonometry. IOP is measured in mmHg with a normal range from 12 mmHg to 22 mmHg. Day 1 (Pre-dosing, then 4- and 8- hours post dosing), Day 7 (Pre-dosing, then 4- and 8- hours post dosing), Day 14 (Pre-dosing, then 4- and 8- hours post dosing)
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