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NCT00981422 Clinical Trial

Search for Biomarkers in Human Glaucoma: Lymphocytes Alterations and Rate of Progression

Glaucoma, Open-Angle Clinical Trial

Official title:
Search for Biomarkers in Human Glaucoma: Possible Correlations Between Alterations in Peripheral Lymphocytes and Disease Severity

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00981422
Other study ID # PARMABIOMARKERS001
Secondary ID
Status Completed
Phase N/A
First received September 21, 2009
Last updated September 21, 2009
Start date June 2007
Est. completion date June 2008

Study information
Verified date September 2009
Source University of Parma
Contact n/a
Is FDA regulated No
Health authority Italy: Ethics Committee
Study type Observational

Clinical Trial Summary

The aim of this study was to evaluate the lymphocyte phenotype in primary open- angle glaucoma (POAG) patients compared to healthy subjects of the same age, in order to confirm the importance of immune responses in glaucoma and the possible correlation to the severity of the disease.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date June 2008
Est. primary completion date December 2007
Accepts healthy volunteers No
Gender Both
Age group 19 Years to 85 Years
Eligibility Inclusion Criteria:

- Clinical diagnosis of primary open-angle glaucoma

- age between 19 an 85 years old

Exclusion Criteria:

- age less than 19 or more than 85 yrs

- positive history for (a) neurodegenerative diseases, (b) autoimmune diseases, (c) cancer, (d) viral infection and (e) diabetes, (f)systemic inflammation

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

Locations
Country Name City State
Italy Azienda ospedaliera universitaria Parma

Sponsors (1)
Lead Sponsor Collaborator
University of Parma

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary compare the lymphocyte phenotype of POAG patients to healthy subjects of the same age the same day of bloodwithdrawal Yes
Secondary correlate the immunophenotype of POAG patients to the severity of disease within 3 months after blood withdrawal Yes
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