GIST Clinical Trial
Official title:
A Retrospective Cohort Study
To compare the efficacy of surgery followed by sunitinib with surgery followed by imatinib in GIST patients with progression on imatinib;To investigate the optimal therapy after surgery in GIST patients with focal or multifocal progression in imatinib
Primary Endpoint: To evaluate the progression free survival of the patients with progression
receiving surgery followed by sunitinib therapy comparing with surgery followed by imatinib
Secondary Endpoint：To evaluate the overall survival of the patients with progression
receiving surgery followed by sunitinib therapy comparing with surgery followed by imatinib
the relationship of c-kit secondary mutation and progression free survival of surgery
followed by TKI therapy the safety and tolerability of the two therapy.
Statistics:All the statistical analysis is performed using SPSS version 20.0 (IBM
corporation, United States). Pearson's chi-squared test was used to compare categorical
variables. PFS and OS analyses were estimated with Kaplan-Meier method and log-rank test and
multivariable analyses were performed to assess survival difference. A two sided p-value of
<0.05 was considered statistically significant.
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