Clinical & Biochemical Evaluation of Dental & Periodontal Conditions in

Status Active, not recruiting

Clinical Trial Summary

Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease.

Clinical Trial Description

Periodontal diseases and inflammatory diseases such as arthritis show similar clinical pathologies such as connective tissue deterioration and bone destruction. They carry the risk of being seen together and the possibility of mutual influence. It is important whether these patients have a difference in cytokine profile from individuals who do not have the disease. In the literature, it has been determined that pro and anti-inflammatory cytokines, which are involved in the pathogenesis of periodontitis, are also involved in the pathogenesis of juvenile idiopathic arthritis (JIA). Cytokines play an undeniable role in the pathogenesis of both diseases. The cytokine profile in periodontal disease is distinctly similar to that of rheumatoid arthritis (RA). As in RA, the level of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) increase in periodontal disease. Again, it is stated that oxidative stress assessment is an important factor in evaluating the development of the disease. Saliva evaluation can be made with new oxidative stress markers that can be used in this sense. On the subject of the proposed thesis; It is to determine the profile of dental and periodontal health in a specific group in terms of biochemical and microbiology using different body fluids together with clinical findings and has an interdisciplinary character. Aimed to be done in the planned thesis; It was aimed to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05217277
Study type	Observational
Source	Marmara University
Contact
Status	Active, not recruiting
Phase
Start date	May 6, 2020
Completion date	September 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05568290` - Interleukin-38 Levels in Individuals With Periodontitis
Completed	`NCT04402996` - Meteorin-like Levels in Individuals With Periodontitis
Not yet recruiting	`NCT06016023` - Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Not yet recruiting	`NCT05497895` - The Assessment of Clinical Efficacy of Topical Application of 5% Thymoquinone Gel for Gingivitis Patients	Early Phase 1
Completed	`NCT02884817` - Essential Oil+ELA, Plaque and Gingivitis	Phase 4
Completed	`NCT02633345` - Effects on Tablets Containing Probiotic Candidate Strains	N/A
Completed	`NCT02552589` - Effect of Toothpaste on the Reduction of Plaque and Inflammation	N/A
Completed	`NCT02515929` - Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs	Phase 4
Unknown status	`NCT01956656` - Efficacy Of Lotus Leaves In Management Of Plaque Induced Gingivitis	N/A
Completed	`NCT02235532` - Effects of Aloe Vera Toothpaste on Periodontal Parameters	N/A
Completed	`NCT02980497` - Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study	N/A
Completed	`NCT02508987` - Obesity and Oxidative Stress in Patients With Different Periodontal Status	N/A
Completed	`NCT01941797` - Experimental Peri-implant Mucositis in Humans	N/A
Completed	`NCT01593540` - Clinical Examination of Metal Free Interdental Brushes	Phase 4
Unknown status	`NCT01197105` - Evaluation Study of a Mouthwash Based on Schinus Terebinthifolius to Treat Gingivitis in Children	Phase 1/Phase 2
Completed	`NCT01236963` - Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation	N/A
Completed	`NCT02102295` - Effects of Antioxidant Dentifrice on Gingivitis	Phase 3
Completed	`NCT06140784` - A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices	N/A
Completed	`NCT02937636` - To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population	N/A
Completed	`NCT06212908` - Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms