Gingival Recessions Clinical Trial
Official title:
Platelet Rich Fibrin Against Connective Tissue Graft in Treatment of Gingival Recessions
The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap and to compare it with the use of a subepitelial connective tissue graft in combination with a coronally advanced flap in Miller class I-II bilateral gingival recession treatment
Purpose
The main objective of this study was to evaluate the clinical effectiveness of platelet-rich
fibrin (PRF) in combination with modified coronally advanced flap (MCAF) in the treatment of
multiple gingival recessions. Furthermore the second aim of the present study was to compare
plastic periodontal surgical procedure, with PRF membrane and connective tissue graft, by a
randomized splitmouth controlled study.
Clinical effectiveness of platelet-rich fibrin (PRF) in combination with modified coronally
advanced flap (MCAF) as measured by Clinical measurements.
Material and Methods
Twenty patients with multiple gingival recession defects (Miller I, II) participated in this
split-mouth trial. Sixty defects received either MCAF+PRF (test) or MCAF with subepithelial
connective tissue graft (SCTG) (control). Gingival recession depth (RD), gingival recession
width (RW), keratinized tissue width (KTW), recession area (RA), probing depth (PD),
clinical attachment level (CAL) and gingival thickness (GT) were evaluated at baseline and 6
months. Additionally post-surgery patient satisfaction and pain status were measured by
comparing visual analogue scale (VAS) scores.
Clinical measurements were taken at starting point and 6 months postoperatively. The
measurements comprised an assessment of probing depth (PD),clinical attachment level (CAL)
and gingival recession parameters including recession depth (RD), recession width (RW),
keratinized tissue width (KTW) and gingival thickness (GT) were assessed by a calibrated
examiner (E. Ö.). PD, CAL, RD, RW and KTW values were recorded by a Williams probe graduated
in 1-mm increments and rounded up to the nearest millimeter (Hu Friedy, Chicago, IL, USA).
To standardize the clinical measurements acrylic stents were prepared on patients' casts.
The following measurements were recorded at the mid-buccal point of the teeth at baseline
and6 months after surgery. GT was evaluated using endodontic reamer attached to a rubber
stopper inserted perpendicularly into the gingival tissue 3 mm below the gingival margin
under local anesthesia, and then the thickness was measured to the nearest 0.1 mm using a
caliper.RD was measured from the CEJ to the gingival margin, RW was measured tangentially at
the mid-facial CEJ and RA was calculated as the area within the contour of denuded root. KTW
recorded as the distance from the mucogingival junction to the gingival margin. Duplicate
measurements were made for RD, RW, RA and KTW with an interval of 24 hours and the average
value of two measurements was used for the assessment. The postoperative pain was evaluated
with a visual analog score (VAS).
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02479633 -
Predetermination for Gingival Recession
|
N/A | |
| Completed |
NCT03258996 -
m-VISTA Technique vs. CAF in the Treatment of Class III Multiple Recessions
|
N/A |