Gingival Recession, Localized Clinical Trial
Official title:
Coronally Advanced Flap Combined With a Meshed Connective Tissue Graft for the Treatment of Multiple Adjacent Gingival Recession Defects : a Multi-center Controlled Randomized Clinical Trial.
The objective of this project is to evaluate short-term and 1-year outcomes of treatment of multiple adjacent gingival recession defects (MAGRD) using the coronally advanced flap (CAF) with either conventional CTG (control group) or meshed CTG (mesh-CTG) (test group).
Gingival recession defects (GRD) present as a partial exposure of the root surface resulting from gingival margin displacement apical to the cemento-enamel junction (CEJ). A variety of surgical methods have been reported to reestablish root coverage, including tunneling techniques and coronally and laterally advanced flaps. As thin gingival tissue is one of the predisposing factors for GRD, the adjuvant use of subepithelial connective tissue grafts (CTG) is often considered. CTG is thought to contribute to phenotype modification and stability of treatment outcomes and studies have indicated favorable esthetic results and high degrees of root coverage (documented range: 69% to 97%). The procedure does, however, require a suitable donor site. When multiple adjacent teeth exhibit GRD, the preferred surgical approach should offer the greatest root coverage while limiting drawback (i.e., patient morbidity, esthetic problems). Thus, one of the challenges related to root coverage is the scarcity of donor tissue. In cases when large CTGs are required, additional surgical procedures may even be necessary. As an alternative, modification of the harvested CTG into an expanded "mesh CTG" (mesh-CTG) has been proposed for the treatment of multiple adjacent GRDs (MAGRD). However, the effectiveness and predictability of mesh-CTG using the coronally advanced flap (CAF) has not yet been evaluated in direct comparison to conventional CTG. We hypothesise that no statistically significant differences will be observed in terms of %root coverage and patient satisfaction at 12 months. Subjects in the test group (mesh-CTG) will report significantly lower morbidity at 1 and 2 weeks post-surgery when compared to controls. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT05591326 -
The Effect of Using Injectable Platelet-rich Fibrin on Root Surface Closure in Patients With Gingival Recession.
|
N/A | |
Recruiting |
NCT06000228 -
Effect of Vestibular Depth on Predictability of Miller Class III/ RT2 Gingival Recession Coverage
|
N/A | |
Recruiting |
NCT05563428 -
Free Gingival Graft Versus Connective Tissue Graft
|
N/A | |
Completed |
NCT04854902 -
Cyanoacrylate Use in Free Gingival Graft
|
N/A | |
Active, not recruiting |
NCT05682274 -
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
|
N/A | |
Completed |
NCT05822323 -
Effect of Botulinum Toxin-A on Free Gingival Graft
|
N/A | |
Not yet recruiting |
NCT04729569 -
Gingival Response and Marginal Adaptation of Zirconia Crowns With Two Subgingival Margin Designs
|
N/A | |
Not yet recruiting |
NCT06228534 -
Root Coverage With Tunneling Technique With Connective Tissue Versus Coronal Advancement Flap Technique.
|
N/A | |
Completed |
NCT06197893 -
Modified Sling and Conventional Suture Techniques in Free Gingival Graft Operations
|
N/A | |
Recruiting |
NCT05850065 -
Assessment of Gingival Health Following Rubber-Dam Isolation
|
N/A | |
Completed |
NCT04718545 -
Effectiveness of Modified-free Gingival Graft for Treatment of Localized Gingival Recession Defects
|
N/A | |
Recruiting |
NCT05990049 -
Hyaluronic Acid and Free Gingival Graft Healing
|
Phase 3 | |
Completed |
NCT03425695 -
Free Gingival Graft Adjunct With Low Level Laser Therapy
|
N/A | |
Completed |
NCT06373783 -
Ultrasonographic Evaluation of the Connective Tissue Grafts Obtained With Two Different Methods in Root Coverage
|
N/A | |
Not yet recruiting |
NCT06432439 -
Impact of Microneedling on Coverage of RT1 Gingival Recession in Thin Phenotype.
|
N/A | |
Enrolling by invitation |
NCT06065774 -
Comparing Two Different Tunneling Technique for Gingival Recession Treatment Using Two Different Matertial
|
N/A | |
Recruiting |
NCT06404762 -
Tuberosity Versus Palatal Connective Tissue Graft on the Treatment of Single Maxillary Recession-type Defects
|
N/A | |
Completed |
NCT04198376 -
The Laterally Closed Tunnel Versus Modified Coronally Advanced Tunnel for Mandibular Anterior Gingival Recession Defects
|
N/A | |
Completed |
NCT03200392 -
Er,Cr:YSGG Laser For Recipient Bed Bio-modification And Connective Tissue Harvesting in Treatment of Gingival Recession
|
N/A | |
Enrolling by invitation |
NCT06388447 -
Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline
|
Phase 4 |