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Clinical Trial Summary

To evaluate effect of Oxidant (Oxygen Releasing Oral Gel) with Coe-Pak versus Anti-oxidant (Nano-emulsion complex propolis and vitamin C gel) with Coe-Pak on wound healing, pain, patient satisfaction after gingival depigmentation


Clinical Trial Description

Gingival depigmentation is considered a periodontal plastic surgery, in which gingival hyperpigmentation is eliminated. The scalpel surgical method is one of the most cost-effective methods, easiest and does not need broad equipment. However, scalpel surgery leads to bleeding during and after surgery, and the surgical area has to be covered with periodontal dressing for 7-10 days. Periodontal dressings are used around the necks of the teeth and surrounding tissue to cover the wound. Non-eugenol dressings are now the most commonly used periodontal dressings include Coe-Pak, Cross Pack, Peripac, Septopack, PerioCare, Perio Putty and Periogenix. Anti-oxidant gel (Nano-emulsion complex propolis and vitamin C - NBF GINGIVAL GEL®) is a high efficiency nano bio fusion gel containing propolis, nano vitamin C, E and herb extract. Anti-oxidant power of nano Vitamin C (NBF GINGIVAL GEL®) is ten times more effective in hundred times smaller amounts, than Vitamin C by itself. Vitamin C collaboratives with Vitamin E and preserves cell membranes integrity. Propolis has antioxidant effect due to its radical scavenging ability, which was more efficient than antioxidant effect of vitamin C. it also enhances synthesis of collagen due to the presence of iron and zinc elements. it has proven to increase healing of epithelial tissues. The presence of oxygen in Oxygen Releasing Oral Gel (blue®m gel) enhances cellular metabolism, collagen synthesis, antibacterial activity, angiogenesis, revascularization, and the release of growth factors, it also helps keratinized tissue formation and has antimicrobial effects. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05837416
Study type Interventional
Source Cairo University
Contact Hadeer M. Shafik Metwally, Bachelor
Phone 01151877398
Email hader.metwally@dentistry.cu.edu.eg
Status Recruiting
Phase Phase 4
Start date February 28, 2023
Completion date May 2024

See also
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Completed NCT06167148 - Gingival Depigmentation Using Diode Laser 940nm Versus 980nm N/A
Not yet recruiting NCT05930366 - Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival Depigmentation N/A
Not yet recruiting NCT05930392 - Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival Depigmentation N/A
Recruiting NCT04495205 - Effect of Non-eugenol Periodontal Pack With and Without PRF on Post-operative Pain and Wound Healing After Gingival Depigmentation Early Phase 1
Completed NCT05283668 - Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation Phase 4
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Recruiting NCT06312605 - The Adjunctive Role of Vitamin C on Pigment Recurrence (Randomized Clinical and Histological Trial) Phase 4
Not yet recruiting NCT05786885 - Microneedling With Vitamin C Versus Injectable Vitamin C for Depigmentation in Gingival Melanin Hyperpigmentation N/A