Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

Gingival Disease Clinical Trial

Official title:

Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05681325
• Other study ID #: matcha on periodontal health
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 25, 2022
• Est. completion date: July 12, 2024

Study information

• Verified date: December 2023
• Source: University of Baghdad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aim of the study:

This study aims to evaluate the antioxidant and beneficial effects of matcha tea daily intake on periodontal health.

Objectives:

• To evaluate the salivary level of antioxidants (catalase, total antioxidant capacity) after matcha tea intake compared to green tea over a period of one month.

• To evaluate the clinical periodontal parameters including bleeding on probing (BOP), probing pocket depth (PPD) and plaque index (PI) after matcha tea intake compared to green tea over a period of one month.

• To evaluate the salivary levels of IL-1B after matcha tea intake compared to green tea over a period of one month.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 40
• Est. completion date: July 12, 2024
• Est. primary completion date: December 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• • having at least 20 teeth,

• underwent no medical treatment during the last 3 months before examination and sampling,

• non-smoker,

• no history of systemic disease,

• gingivitis patient (having >10% bleeding sites with no PPD >3 mm).

Exclusion Criteria:

• • wore orthodontic appliances,

• pregnant or currently in the breast-feeding period,

• periodontitis patient,

• smoker,

• has a history of systemic disease.

Related Conditions & MeSH terms

• Gingival Disease
• Gingival Diseases

Intervention

Dietary Supplement:
• green tea
It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.
• matcha tea
It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.

Locations

Country	Name	City	State
Iraq	Universality of Baghdad, College of dentistry	Baghdad

Sponsors (1)

Lead Sponsor	Collaborator
Hayder Raad Abdulbaqi

Country where clinical trial is conducted

Iraq, 

References & Publications (2)

Kolackova T, Kolofikova K, Sytarova I, Snopek L, Sumczynski D, Orsavova J. Matcha Tea: Analysis of Nutritional Composition, Phenolics and Antioxidant Activity. Plant Foods Hum Nutr. 2020 Mar;75(1):48-53. doi: 10.1007/s11130-019-00777-z. — View Citation

Zhang Y, Kang N, Xue F, Qiao J, Duan J, Chen F, Cai Y. Evaluation of salivary biomarkers for the diagnosis of periodontitis. BMC Oral Health. 2021 May 17;21(1):266. doi: 10.1186/s12903-021-01600-5. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in salivary level of antioxidant marker	change in level of catalase enzyme in ku/L	30 Days (baseline to one moth of tea intake)
Primary	change in salivary level of ant-inflammatory marker	change in level of interleukin- one beta (IL-1B) in pg/L	30 Days (baseline to one moth of tea intake)
Secondary	change in percentage of bleeding on probing (BOP)	change in BOP percentage. less percentage means less inflammation in gingival tissue	30 Days (baseline to one moth of tea intake)
Secondary	change in plaque index (PI) scores	change in PI scores. less scores mean less dental plaque accumulated onto teeth surfaces	30 Days (baseline to one moth of tea intake)