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Clinical Trial Summary

Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding. Intravenous PPI is recommended as a standard treatment.In the past, there were many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous drip.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04394663
Study type Interventional
Source King Chulalongkorn Memorial Hospital
Contact Rapat Pittayanon, MD
Phone 66804224999
Email rapat125@gmail.com
Status Recruiting
Phase N/A
Start date October 1, 2020
Completion date December 31, 2025

See also
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Recruiting NCT06052358 - Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
Completed NCT00950339 - Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine Phase 4