Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

Ghrelin Clinical Trial

Official title:

Effects of a 12-week Combined Exercise Program on Acylated and Desacyl Ghrelin, and Ghrelin O Acyl Transferase in Obese Adolescent Girls

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04447391
• Other study ID #: 04-2015-015
• Status: Completed
• Phase: N/A
• Start date: September 10, 2015
• Est. completion date: December 31, 2015

Study information

• Verified date: June 2020
• Source: Pusan National University Yangsan Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

Description:

Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: December 31, 2015
• Est. primary completion date: December 30, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 16 Years to 18 Years

Eligibility

Inclusion Criteria:

• girls between 16 and 18 years

• being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years.

• After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.

Exclusion Criteria:

• participation in any weight-management programme in the past 6 months

• engagement in other exercise programs except for regular physical education at school

• smoking

• amenorrhea for consecutive 2 months or more

• being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments

• taking any medication or supplements for weight control

Related Conditions & MeSH terms

• Ghrelin

Intervention

Other:
• Combined exercise program
Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet
• Control
300 kcal deficit diet only

Locations

Country	Name	City	State
Korea, Republic of	Pusan National University Yangsan Hospital	Yangsan	Gyeungsangnam-do

Sponsors (1)

Lead Sponsor	Collaborator
Pusan National University Yangsan Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	body fat percent	Changes in body fat percent during 12 weeks	Change from baseline body fat percent at 12 weeks
Primary	acylated ghrelin	Changes in concentrations of acylated ghrelin during 12 weeks	Change from concentrations of baseline acylated ghrelin at 12 weeks
Primary	desacylated ghrelin	Changes in concentrations of desacylated ghrelin during 12 weeks	Change from concentrations of baseline desacylated ghrelin at 12 weeks
Secondary	ghrelin O acyl transferase	Changes in concentrations of ghrelin O acyl transferase during 12 weeks	Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks