Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

Geriatric Clinical Trial

Official title:

Impact of Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program on Hospitalized Older Patients: A Non-Randomized Controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05113667
• Other study ID #: MUHSI-2019/29-78
• Status: Completed
• Phase: N/A
• Start date: September 1, 2019
• Est. completion date: August 31, 2021

Study information

• Verified date: October 2023
• Source: Marmara University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate the impact of clinical pharmacist-led appropriate acid suppression therapy stewardship program in hospitalized older patients.

Description:

This prospective, nonrandomized controlled study was conducted in older patients who ordered proton pump inhibitor (PPI) at admission in an internal medicine service of tertiary training and research hospital. In the intervention group, clinical pharmacist-led services (including medication reconciliation and medication review) were conducted during hospitalization and at discharge by using the guidelines and potentially inappropriate medications (PIM) criteria [American Geriatric Society-AGS Beers Criteria©, 2019]. Medication Appropriateness Index (MAI), inappropriate PPI cost, and hospitalization for gastrointestinal bleeding within 1 year after discharge were calculated in both groups

Recruitment information / eligibility

• Status: Completed
• Enrollment: 250
• Est. completion date: August 31, 2021
• Est. primary completion date: February 28, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years to 95 Years

Eligibility

Inclusion Criteria:

• 65 years old or greater

• Admitted to the hospital with any reason

• Ordered at least one PPI dose within 48 hours of admission

Exclusion Criteria:

• Transferred to another ward (including an intensive care unit)

• Having active gastrointestinal bleeding

• Having active malignity

Related Conditions & MeSH terms

• Geriatric

Intervention

Other:
• Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program
Clinical pharmacist provided medication reconciliation and medication review during the hospital stay.

Locations

Country	Name	City	State
Turkey	Marmara University	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Marmara University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Appropriateness of Proton Pump Inhibitors Usage	The rate of appropriateness use of proton pump inhibitors based on the guidelines at hospital stay	during hospital stay, an average of 14 days
Primary	Potentially Inappropriate Proton Pump Inhibitors Usage	The rate of potentially inappropriate use of proton pump inhibitors based on American Geriatric Society Beers Criteria© 2019	at discharge, an average of 14 days after admission to hospital
Secondary	Clinical outcome	The number of patients who hospitalized for bleeding within 1 year after discharge	1 year
Secondary	Cost saving during hospital stay	Medication cost for inappropriate PPI during hospital study	during hospital stay, an average of 14 days
Secondary	Medication Appropriateness Index for Proton Pump Inhibitors at hospital stay	Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.; Higher scores of this index represent more inappropriateness of each medication.	during hospital stay, an average of 14 days
Secondary	Cost saving after discharge	Medication cost for potentially inappropriate PPI after discharge	a month
Secondary	Medication Appropriateness Index for Proton Pump Inhibitors at discharge	Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.; Higher scores of this index represent more inappropriateness of each medication.	at discharge, an average of 14 days after admission to hospital