Geographic Atrophy Clinical Trial
Official title:
A Phase IIa, Multicenter, Open-Label, Single-Arm Study To Optimize Subretinal Surgical Delivery And To Evaluate Safety And Activity Of Opregen In Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This study will evaluate the success and safety of subretinal surgical delivery as well as the preliminary activity of OpRegen in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). All endpoints are assessed for the study eye unless otherwise indicated.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06161584 -
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
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| Active, not recruiting |
NCT05536297 -
Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy
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Phase 3 | |
| Completed |
NCT02515942 -
CLG561 Proof-of-Concept Study as a Monotherapy and in Combination With LFG316 in Subjects With Geographic Atrophy (GA)
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Phase 2 | |
| Completed |
NCT02503332 -
Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy
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Phase 2 | |
| Recruiting |
NCT04339764 -
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration
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Phase 1/Phase 2 | |
| Completed |
NCT03295877 -
Safety and Tolerability Study of RO7171009 in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
|
Phase 1 | |
| Completed |
NCT01445548 -
Sirolimus for Advanced Age-Related Macular Degeneration
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Phase 1/Phase 2 | |
| Completed |
NCT00973011 -
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of FCFD4514S in Patients With Geographic Atrophy
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Phase 1 | |
| Terminated |
NCT02247479 -
A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
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Phase 3 | |
| Completed |
NCT06006585 -
A Study to Test How Well Different Doses of BI 771716 Are Tolerated by People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy
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Phase 1 | |
| Recruiting |
NCT05961332 -
COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Geographic Atrophy
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N/A | |
| Terminated |
NCT02247531 -
A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
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Phase 3 | |
| Completed |
NCT02332343 -
Sparing of the Fovea in Geographic Atrophy Progression
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N/A | |
| Completed |
NCT01002950 -
Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACU-4429 in Subjects With Geographic Atrophy
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Phase 2 | |
| Completed |
NCT03777332 -
Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy
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Phase 1 | |
| Active, not recruiting |
NCT04676854 -
Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMD
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N/A | |
| Recruiting |
NCT02372916 -
Geographic Atrophy and Intravitreal Ranibizumab Injections
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N/A | |
| Active, not recruiting |
NCT05380492 -
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
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Phase 1/Phase 2 | |
| Terminated |
NCT04607148 -
A Study Assessing the Long-Term Safety and Tolerability of Galegenimab (FHTR2163) in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
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Phase 2 | |
| Terminated |
NCT02087085 -
A Safety and Efficacy Study of Brimonidine Intravitreal Implant in Geographic Atrophy Secondary to Age-related Macular Degeneration
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Phase 2 |