Geographic Atrophy Clinical Trial
Official title:
Characterization of Geographic Atrophy Progression in Patients With Age-related Macular Degeneration
Age-related macular degeneration is one of the leading causes of blindness worldwide. The factors that induce the progression of geographic atrophy, the advanced form of dry age-related macular degeneration, remain poorly understood. The aims of this study are to describe the natural history of geographic atrophy and identify potential risk factors associated with a faster spread of atrophy that may be used to develop rational therapies.
Age-related macular degeneration is the leading cause of blindness in developed countries.
Geographic atrophy is the advanced form of dry age-related macular degeneration, and
currently has no effective therapy. Little is known about the risk factors that drive the
progression of geographic atrophy, and yet they are crucial to understand the mechanisms of
the disease. Therefore, the identification of risk factors associated with a faster spread
of atrophy may help contribute to identify the causes of the disease and, ultimately, to
develop new therapeutic strategies to manage the disorder.
The current prospective, observational, natural history study has the following objectives:
- Describe the natural history of geographic atrophy in anatomic and visual terms
- Identify risk factors associated with a faster enlargement of atrophy
The main hypothesis is that lipofuscin accumulation at the borders of atrophy as seen with
fundus autofluorescence imaging is associated with a faster progression of the disease.
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Observational Model: Case-Only, Time Perspective: Prospective
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