Genomic Clinical Trial
Official title:
A New Strategy to Analyze Gene-Nutrient Interaction in Children and Adolescents
The purpose of this trial is to better define how individuals with different genetic make-ups will require different interventions to improve their methylation potential and nutrient status.
Despite the increasing incidence of overweight and obesity among children, nutritional
deficiencies are still a concern.
A low intake of vitamins and minerals is associated with a reduction in the antioxidant
capacity. Some vitamins are associated with chronic diseases including overweight and
obesity.
S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are the substrate and product of
essential reactions; the SAM:SAH ratio has been associated with health and is an indicator
of cellular DNA methylation potential.
Low level of this ratio may affect short and long term health. In this explorative knowledge
building open interventional study, subject to be enrolled are children or adolescents 9 to
13 years of age per year (n=180 per year, over 2 years). The study consists of 6 weeks
nutritional intervention followed by a 6 weeks follow up.
In this study, genomics, proteomics, lipidomics analysis will be performed, in addition to
biochemistry, hematology and vitamins analysis.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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