Clinical Trials Logo

Clinical Trial Summary

The study aims to investigate the difference of in vitro fertilization (IVF) outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A.


Clinical Trial Description

Background Chromosome abnormality is a leading cause of implantation failure and miscarriage. Chromosome abnormality increases with age, resulting in reduced pregnancy rate. Nowadays, preimplantation genetic testing for aneuploidies (PGT-A) could be used for detection of aneuploidy. However, PGT-A needs embryo biopsy which is invasive and may cause embryo damage. It was found that cell free DNA could be isolated from culture media. The cell free DNA from culture media also could be used to detect embryo ploidy, called non-invasive PGT-A. Objective The study aims to investigate the difference of in vitro fertilization (IVF) outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A. Another aim of this study is to check the concordance rate between non-invasive PGT-A and PGT-A. Methods The prospective cohort study will be performed at the reproductive medical center of Kaohsiung Veterans General Hospital, in Kaohsiung, Taiwan. Participants who plan to receive an IVF cycle and preimplantation genetic testing for aneuploidies will be enrolled in this study. The investigators will divide the participants into 3 groups: (1) combined non-invasive PGT-A and PGT-A; (2) PGT-A; (3) non-invasive PGT-A. Basal characteristics, infertility history, ovarian reserve and embryo development of the three groups will be recorded. The samples will be detected ploidy by using next generation sequencing (NGS). Then, the investigators will choose embryo to transfer according to the embryo ploidy and follow the pregnancy outcomes after embryo transfer. Outcome 1. Concordance rate between non-invasive PGT-A and PGT-A 2. The relationship between morphological grade and ploidy of non-invasive PGT-A 3. IVF outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04856696
Study type Interventional
Source Kaohsiung Veterans General Hospital.
Contact Li-Te Lin
Phone +88673464027
Email [email protected]
Status Recruiting
Phase N/A
Start date March 24, 2021
Completion date June 30, 2023

See also
  Status Clinical Trial Phase
Completed NCT03988504 - Impact of Predictive Genetic Testing
Recruiting NCT02691689 - Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions N/A
Recruiting NCT04704193 - Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes N/A
Recruiting NCT03869515 - Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China
Recruiting NCT04481061 - Engaging Adolescents in Decisions About Return of Genomic Research Results N/A
Recruiting NCT04656028 - Genetic Testing and Motivational Counseling for FH N/A
Completed NCT02742116 - Evaluation of the Implementation of Expanded Carrier Screening Before Pregnancy in Hong Kong N/A
Recruiting NCT03396341 - Responses to Genetic Risk Modifier Testing Among Women With BRCA1/2 Mutations
Recruiting NCT04245176 - Genetic Testing for All Breast Cancer Patients (GET FACTS) N/A
Recruiting NCT02665195 - Prospective Registry of Multiplex Testing (PROMPT)
Withdrawn NCT01663584 - Multi-disease Carrier Screening Test Validation N/A