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Genetic Change clinical trials

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NCT ID: NCT05712980 Not yet recruiting - Clinical trials for Failed Back Surgery Syndrome

Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation

SCS-OMICS
Start date: February 2023
Phase:
Study type: Observational

Failed Back Surgery Syndrome (FBSS) is a relatively common condition that can cause a severe disability in patients. Spinal cord stimulation (SCS) is used in those patients refractory to conventional therapies.In this project the investigators aim to identify new functional molecular basis, defined with transcriptomic profiling, differentially represented in the serum of patients suffering chronic pain caused by FBSS. The investigators will try to Identify "omics" markers for diagnosing and monitoring the process of development and maintenance of pain as well as the evaluation of these as evolutionary disease markers or predictors of the response to SCS therapy. To carry out the project, 40 patients diagnosed with refractory FBSS and treated with an SCS system for pain management will be included. Blood samples will be obtained to analyze the transcription profiling in plasma of patients responding to different modalities of SCS therapy.

NCT ID: NCT05512325 Not yet recruiting - Genetic Change Clinical Trials

Study on Gene Evolution in Glioma Under Stress Therapy

Start date: December 17, 2022
Phase:
Study type: Observational [Patient Registry]

Little is known about the evolution of genetic and epigenetic changes that occur in the progression of glioma. We inferred the evolution trajectories of matched pairs of primary tumors and progression tumor in situ fluid (TISF) based on deep whole-genome-sequencing data (ctDNA). A monocentric, Gene grouping controlled trial design was used to select patients. and to compare gene evolution of different subtypes of glioma under therapy. To predict the molecular reaction of bevacizumab treatment, clarify the mechanism of drug resistance of bevacizumab treatment.