Cognitive-Behavioral Treatment and Interpretation Modification Training for Adults With Generalized Anxiety Disorder

Generalized Anxiety Disorder Clinical Trial

— CBT+IMT-GAD  

Official title:

Improving Outcomes for Adults With Generalized Anxiety Disorder: Combining Cognitive-Behavioral Treatment and Interpretation Modification Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01681329
• Other study ID #: MOP-82771-12-04
• Status: Completed
• Phase: N/A
• Start date: September 2012
• Est. completion date: June 2018

Study information

• Verified date: July 2018
• Source: Concordia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Generalized Anxiety Disorder (GAD) is a condition characterized by chronic and excessive worry and anxiety. Our group has developed a cognitive-behavioural treatment (CBT) for GAD that has been tested in four previous clinical trials. The findings show that 60 to 70% of affected individuals attain GAD remission and that 50 to 55% achieve high endstate functioning following the treatment. Although these numbers are encouraging, there remain a considerable proportion of individuals who do not fully benefit from treatment. In our most recent CIHR-funded treatment study, we assessed the impact of information processing on the efficacy of CBT for GAD. Our findings show: a) that the tendency to negatively interpret ambiguous information at pre-treatment was associated with greater GAD symptoms at post-treatment; and b) that patients who were less successful at changing their negative interpretation style were also less responsive to CBT. Given that computerized interpretation modification training has been shown to be effective for decreasing the negative interpretation style of anxious individuals, the goal of the current proposal is to determine whether such training can augment the efficacy of CBT for adults with GAD. A total of 138 individuals with a primary diagnosis of GAD will be randomly allocated to one of two conditions: a) CBT plus interpretation modification training or b) CBT plus non-active training. CBT will consist of 14 weekly sessions, with interpretation modification training (or non-active training) administered prior to each session. Measures of GAD symptoms, psychopathology, cognitive vulnerability, and interpretation style will be administered at pre-, mid-, and post-treatment, as well as at 6- and 12-month follow-ups. The proposed study will provide information about the efficacy, clinical usefulness, and mechanisms of interpretation modification training in combination with CBT.

Description:

Generalized Anxiety Disorder (GAD) is characterized by excessive and uncontrollable worry and anxiety. In Canada, the point prevalence of GAD is 3 to 4%, and the personal and social costs of GAD are well documented. Over the past decade, new cognitive-behavioural treatments have been developed for GAD. Our group has also developed a cognitive-behavioural treatment (CBT) protocol for GAD, which focuses on intolerance of uncertainty. There are now four published randomized clinical trials of the treatment, with results suggesting that it is more efficacious than wait-list control, supportive therapy, and applied relaxation. Although these results are encouraging, 30 to 40% of affected individuals do not attain diagnostic remission and 45 to 50% do not achieve high endstate functioning at post-treatment.

In an effort to augment the efficacy of the treatment protocol for GAD, we have recently examined a broad range of demographic and clinical variables that might predict a limited response to treatment. The results of our analyses suggest that a particular type of cognitive bias plays a key role in determining treatment response. Specifically, patients with a particularly negative interpretation style (i.e., the tendency to negatively interpret ambiguous information) have a greater probability of not attaining remission following CBT (they also show less improvement on other indicators of treatment outcome). In addition, change in interpretation style appears to mediate change in GAD symptoms over the course of CBT. Thus, the data suggest that treatment efficacy could be increased by adding training strategies that specifically address negatively biased interpretations of ambiguous information. Recently, a number of experimental investigations have shown that the tendency to negatively interpret ambiguous information can be decreased using computerized interpretation modification training. In fact, the data show that such changes can be maintained over time, can generalize to new situations, and can lead to corresponding changes in GAD symptoms and anxiety proneness. Thus, it appears that computerized interpretation modification training has the potential to increase the efficacy of current CBT protocols by directly targeting and decreasing the tendency to negatively interpret ambiguous information.

The proposed randomized clinical trial addresses the following question: Can computerized interpretation modification training augment the efficacy of CBT for GAD? A total of 138 individuals with a primary diagnosis of GAD will be randomly allocated to one of two conditions: a) CBT plus interpretation modification training (CBT+IMT) or b) CBT plus non-active training (CBT+NA). CBT will consist of 14 weekly 50-minute sessions targeting intolerance of uncertainty via procedures such as problem-solving training and imaginal exposure. Participants randomized to the experimental condition will receive 10 minutes of computerized interpretation modification training prior to each CBT session. In interpretation modification training, respondents learn to endorse benign combinations and reject negative combinations of sentences and words, thus promoting new associative learning. Participants in the control condition will receive 10 minutes of non-active training, in which each sentence is paired with a word that is unrelated to the sentence or a word that is related to a non-threatening (and typically peripheral) aspect of the sentence. Measures of GAD symptoms, psychopathology, cognitive vulnerability, and interpretation style will be administered at pre-, mid-, and post-treatment, as well as at 6- and 12-month follow-ups. The proposed study will provide information about the efficacy, clinical usefulness, and mechanisms of interpretation modification training in combination with CBT. Given previous findings on the key role of negative interpretation style in anxiety, the proposed study has the potential to increase our understanding and ability to treat individuals with GAD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 79
• Est. completion date: June 2018
• Est. primary completion date: June 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Principal diagnosis of GAD

• Willingness to keep medication status stable while participating in the study

• Willingness to undergo randomization

Exclusion Criteria:

• Change in medication type or dose in 12 weeks before study entry

• Use of herbal products known to have CNS effects in the 2 weeks before study entry

• Evidence of suicidal intent

• Evidence of current substance abuse

• Evidence of current or past schizophrenia, bipolar disorder or organic mental disorder

• Current participation in other trials

• Concurrent psychotherapy during treatment phase of trial

• Evidence of anxiety symptoms due to a general medical condition

Related Conditions & MeSH terms

• Anxiety Disorders
• Disease
• Generalized Anxiety Disorder

Intervention

Behavioral:
• Cognitive-behavioral therapy
Cognitive-behavioral therapy addressing intolerance of uncertainty, positive beliefs about worry, negative problem orientation, and cognitive avoidance

Other:
• Interpretation training
Computerized interpretation training using Word-Sentence Association Paradigm

Locations

Country	Name	City	State
Canada	Hôpital du Sacré-Coeur de Montréal, Clinique des troubles anxieux	Montréal	Quebec

Sponsors (6)

Lead Sponsor	Collaborator
Concordia University	Brown University, Hopital du Sacre-Coeur de Montreal, Ryerson University, Université de Sherbrooke, Université du Québec à Trois-Rivières

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change from baseline in interpretation of scrambled sentences	Scrambled Sentence Task for GAD (SST-GAD)	Post-treatment (14 weeks)
Other	Change from baseline in interpretation of ambiguous scenarios	Ambiguous/Unambiguous Situations Diary, Extended version (AUSD-Ext)	Post-treatment (14 weeks)
Other	Change from baseline in interpretation of ambiguous pictures	Affective Picture Rating Task (APRT)	Post-treatment (14 weeks)
Primary	Change from baseline in severity of GAD symptoms assessed by structured interview	Clinician's Severity Rating (CSR) scale of Anxiety Disorders Interview Schedule for DSM-IV (ADIS-IV)	Post-treatment (14 weeks)
Primary	Change from baseline in severity of GAD symptoms	Worry and Anxiety Questionnaire (WAQ)	Post-treatment (14 weeks)
Primary	Change from baseline in severity of worry	Penn State Worry Questionnaire (PSWQ)	Post-treatment (14 weeks)
Secondary	Change from baseline in somatic anxiety	Beck Anxiety Inventory (BAI)	Post-treatment (14 weeks)
Secondary	Change from baseline in depressive symptoms	Beck Depression Inventory, 2nd edition (BDI-II)	Post-treatment (14 weeks)
Secondary	Change from baseline in hostile attitudes	Aggression Questionnaire, Hostility subscale (AQ-Host)	Post-treatment (14 weeks)
Secondary	Change from baseline in intolerance of uncertainty	Intolerance of Uncertainty Scale (IUS)	Post-treatment (14 weeks)
Secondary	Change from baseline in beliefs about worry	Why Worry, 2nd edition (WW-II)	Post-treatment (14 weeks)
Secondary	Change from baseline in problem orientation	Negative Problem Orientation Questionnaire (NPOQ)	Post-treatment (14 weeks)
Secondary	Change from baseline in cognitive avoidance	Cognitive Avoidance Questionnaire (CAQ)	Post-treatment (14 weeks)