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Generalized Anxiety Disorder clinical trials

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NCT ID: NCT06282133 Recruiting - Clinical trials for Generalized Anxiety Disorder

Behavioural Experiments for Generalized Anxiety in Adolescents - Pilot Study

EC-II-Ado-P
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry and anxiety. In adolescents, this condition can seriously impact their development, academic performance, and social relationships. In Canada, 3 to 4% of the population (between 0.9% and 2.7% among adolescents) suffers from GAD at any given time in their lives. These young individuals experience a reduced quality of life and are at risk for numerous medical conditions, as well as additional psychological issues. Research suggests that both pharmacological and psychological approaches are effective in treating GAD in the short term. However, psychological treatments appear to offer the greatest long-term benefits. There are a number of effective psychological treatments for GAD, most of which fall under cognitive-behavioural therapy (CBT) adapted for this age group. In the 1990s, a group of Canadian researchers developed a CBT protocol for GAD that included four components. Data from six clinical trials in adults suggest that one of the four components is particularly important for treatment success: exposing oneself to uncertainty rather than avoiding it in daily life. In other words, learning to tolerate and manage uncertainty seems to be the key to reducing worry and anxiety. Given this discovery, researchers developed a new treatment that exclusively targets intolerance to uncertainty and then adapted it for adolescents: Behavioural Experiments for Intolerance to Uncertainty in Adolescents (EC-IIA). The aim of the current pilot study is to test the effectiveness of EC-IIA in adolescent individuals. A total of 8 participants with a primary diagnosis of GAD will receive EC-IIA and will be evaluated at 4 different times ranging from pre-treatment to a 6-month follow-up. Conditions will be compared in terms of treatment efficacy and mechanisms. Researchers will also examine predictors of change during the 6 months following treatment. The proposed study will produce data on the effectiveness and mechanisms of a treatment for GAD that is less costly, less complex, and easier to disseminate than currently available treatments.

NCT ID: NCT06278909 Recruiting - Clinical trials for Generalized Anxiety Disorder

Trigeminal Nerve Stimulation in Treatment-resistant Generalized Anxiety Disorder: a Feasibility Study

Start date: January 18, 2024
Phase: N/A
Study type: Interventional

This is a feasibility study for trigeminal nerve stimulation (TNS) in patients with treatment-resistant generalized anxiety disorder (TR-GAD). Ten participants will receive TNS for 8 weeks as an augmentation strategy to pharmacological treatment for generalized anxiety disorder (GAD). - The primary objective is to ascertain if TNS is a safe and well-tolerated treatment for patients with TR-GAD. - The secondary objective will be to monitor changes in GAD symptom severity throughout the study. Results from this study will inform a randomized controlled trial to be conducted in the future.

NCT ID: NCT06243640 Recruiting - Clinical trials for Generalized Anxiety Disorder

Phase 3 Clinical Trial of Buagafuran Capsules in the Treatment of GAD

BGFN-2022-02
Start date: July 25, 2023
Phase: Phase 3
Study type: Interventional

A placebo-controlled superiority design was used to evaluate the efficacy of 60 mg/ day or 120 mg/ day of Buagafuran capsules in the treatment of GAD

NCT ID: NCT06243614 Recruiting - Clinical trials for Generalized Anxiety Disorder

Phase Ⅲ Clinical Trial of Buagafuran Capsules in the Treatment of GAD

BGFN-2022-01
Start date: July 24, 2023
Phase: Phase 3
Study type: Interventional

A placebo-controlled superiority design was used to evaluate the efficacy of 60-120 mg/ day of Buagafuran capsules in the treatment of GAD.

NCT ID: NCT06134323 Recruiting - Clinical trials for Generalized Anxiety Disorder

Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder

Start date: December 5, 2023
Phase: N/A
Study type: Interventional

This is a randomized, double-blind, parallel-controlled study of patients with generalized anxiety disorder, who will be randomly assigned to either drug-combined transcutaneous vagus nerve stimulation (tVNS) group or drug-combined sham-stimulation group for a period of 4 weeks of treatment.Scale assessments will be performed at baseline, week 1, week 2, week 3, and week 4 of treatment, and brain function monitoring as well as laboratory tests will be performed at baseline and at the end of treatment, respectively.The aim of this study is to investigate the efficacy of medication combined with tVNS and the possible mechanisms of tVNS in the treatment of anxiety.

NCT ID: NCT06132659 Recruiting - Anxiety Clinical Trials

Neurofeedback Enhanced Cognitive Reappraisal Training

Start date: April 22, 2024
Phase: N/A
Study type: Interventional

This study seeks to understand emotion regulation in those with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. The study hypothesis include: - Participants receiving veritable-Neurofeedback (NF) will show a greater activation increase in the prefrontal cortex (PFC) compared to sham-NF - Participants receiving veritable-NF will show greater cognitive reappraisal (CR) ability compared to those receiving sham-NF - Prefrontal cortex activation will positively correlate with CR ability - The veritable-NF group will report decreased symptom severity and increased CR use compared to the sham-NF group - Increase in NF-induced brain activation will correlate with decreased symptom severity and increased CR use at follow-up

NCT ID: NCT06124014 Recruiting - Clinical trials for Generalized Anxiety Disorder

CES for the Treatment of GAD in Young Adults

Start date: January 26, 2024
Phase: N/A
Study type: Interventional

The purpose of this research study is to study cranial electrotherapy stimulation (CES) to determine its effects on symptoms of anxiety in people with generalized anxiety disorder (GAD) between the ages of 18 - 21 years of age.

NCT ID: NCT06046170 Recruiting - Anxiety Clinical Trials

Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)

Start date: January 15, 2024
Phase: N/A
Study type: Interventional

Anxiety is very common in autistic youth. Recently, an intervention has been created by the investigators to target these symptoms in autistic youth in a community setting. The purpose of this study is to determine the feasibility of implementing this treatment in community care centers.

NCT ID: NCT06010654 Recruiting - Clinical trials for Generalized Anxiety Disorder

Pivotal RCT to Test Safety and Efficacy of Digital Therapeutics 'ANZEILAX' for Managing Generalized Anxiety Disorder

Start date: August 14, 2023
Phase: N/A
Study type: Interventional

The investigators propose to develop and adapt 'ANZEILAX' smartphone app specifically for individuals with Generalized anxiety disorder. The study will measure the therapeutic effects and safety of 'ANZEILAX' on symptoms of anxiety using pre- and post-treatment scores for generalized anxiety disorder and other physical, emotional, and cognitive symptoms of anxiety

NCT ID: NCT05970510 Recruiting - Clinical trials for Generalized Anxiety Disorder

A Study to Evaluate Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets in Generalized Anxiety Disorder.

Start date: July 12, 2023
Phase: Phase 3
Study type: Interventional

The study aims to evaluate the efficacy and safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets compared to placebo in adults participants with generalized anxiety disorder over a period of 8 weeks.