View clinical trials related to General Health.
Filter by:The purpose of the study is to collect and analyze physiological, physical, and molecular data from a diverse population to increase our understanding of how such parameters are associated with health and disease.
For both healthy adults and patients with cardiovascular disease (CVD), aerobic fitness (V̇O2max) is a stronger predictor of the risk of future chronic disease and premature death than other established risk factors such as hypertension, smoking, or Type 2 diabetes. It is important to improve the understanding of the regulation of V̇O2max to enable optimisation of interventions aimed at increasing V̇O2max in the current predominantly sedentary population. Currently, only exercise training is a viable method for increasing V̇O2max. However, ~10-20% of people who follow fully supervised, standardised training interventions do not demonstrate a measurable increase in V̇O2max. Low response to training is a clinically relevant concern, but the large variability in response to exercise training also provides an opportunity to dissect out the molecular mechanisms responsible for adaptations to V̇O2max by contrasting low vs. high responders to training. It has been previously demonstrated that low responders for VO2max fail to up regulate a number of genes that encode putative 'myokines', while the high responders demonstrated a significant increase in the expression of these genes, suggesting these myokines may play an important mechanistic role in modulating VO2max. The aim of the present study is to examine whether low responders for VO2max have an attenuated increase in the plasma levels of the previously identified myokines.
Regular exercise is needed to ensure good general health and wellbeing. How exercise makes you feel (pleasant / unpleasant) is thought to be important for whether people will stick with a given exercise routine. Sprint interval training (SIT) has been shown be a time-efficient exercise strategy for improving health, but some researchers suggest that SIT may be experienced as unpleasant and therefore unsuitable as an exercise routine for improving general health and wellbeing. However, SIT protocols are diverse, and it has previously been shown that very short SIT protocols such as 'reduced-exertion high-intensity interval training' (REHIT) are not perceived as unpleasant, at least on average. Interestingly, how REHIT is perceived appears to be highly variable between individuals. This individual variability may have important implications for whether people stick with REHIT and/or SIT in real-world settings, and therefore it is important to characterise it and better understand why some people find this exercise unpleasant while others do not. This study aims to characterise the within-participant and between-participant variability in how people perceive REHIT. Furthermore, potential relationships between psychological characteristics and how people perceive REHIT will be explored.