General Anesthesia Clinical Trial
Official title:
Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp electroencephalogram (EEG) of the frontal cortex were recorded from patients undergoing deep brain stimulation (DBS) surgery during the recovery from general anesthesia, in order to explore the changes and relevance of deep brain nuclei firing and cortex activity during the recovery of consciousness from general anesthesia .
The recovery of consciousness during the emergence from general anesthesia is an important part of general anesthesia. Previous studies have found that the recovery of consciousness is not a passive process of drug metabolism, but involves the activation of functional neural networks in the brain. However, the temporal-spatial dynamics of different brain regions, including deep brain nuclei and the cortex, during recovery from general anesthesia have not been elucidated. At present, thanks to the perceptible function of the new generation of deep brain stimulation (DBS) equipment, the local field potential (LFP) of deep brain nuclei can be recorded in real time during the patient's recovery from general anesthesia after DBS surgery. This study will simultaneously record the electrophysiological signals of the patient's deep brain nuclei LFP and cortical EEG signals, and analyze the differences and correlations between the deep brain nuclei LFP and the cortical EEG characteristics during recovery from general anesthesia. This provides evidence for understanding how subcortical deep brain nuclei are involved in the recovery of general anesthesia, and provides clues for solving the mystery of consciousness. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04577430 -
Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
|
N/A | |
Completed |
NCT03708692 -
Menstrual Cycle Phases on Recovery and Cognitive Function
|
||
Recruiting |
NCT03422315 -
Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection
|
N/A | |
Completed |
NCT02771067 -
The Utility of Pulse Pressure Variation to Predict the Fluid Responsiveness During Pneumoperitoneum and Reverse-Trendelenburg Position
|
N/A | |
Completed |
NCT05063461 -
Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane
|
N/A | |
Completed |
NCT03294226 -
Comparison of AuraGain With I-gel for Pediatric Patients
|
N/A | |
Not yet recruiting |
NCT03643029 -
The Accuracy of the Performance and Placement Test for Predicting Supraglottic Airway Device (SAD) Position in the Hypopharynx as Confirmed With Video Laryngoscopy
|
N/A | |
Completed |
NCT01945411 -
Assessment of Facial Measurements, the Length of Mouth Corner-mandible Angle and Incisors-mandible Angle, for Determining the Proper Sizes of Oropharyngeal Airway
|
N/A | |
Completed |
NCT01705743 -
Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG
|
Phase 4 | |
Not yet recruiting |
NCT01678066 -
A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor
|
N/A | |
Completed |
NCT00972491 -
The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
|
N/A | |
Completed |
NCT01096212 -
Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia
|
Phase 4 | |
Completed |
NCT00741507 -
Unhealthy Alcohol Drinking and Anesthetic Requirement in Women
|
N/A | |
Completed |
NCT00532402 -
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
|
N/A | |
Completed |
NCT00599066 -
Intraoperative M-Entropy Measurements
|
N/A | |
Completed |
NCT00468494 -
Can Blood Glucose Levels During the Perioperative Period Identify a Population at Risk for Hyperglycemia?
|
N/A | |
Recruiting |
NCT00492453 -
Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy
|
N/A | |
Recruiting |
NCT03745079 -
Correlation Between Core Temperature and Skin Temperature Measured by 3M SpotOn
|
||
Completed |
NCT04094376 -
Comparison of Morning Operation and Evening Operation on Postoperative Sleep Quality and Pain Under General Anesthesia
|
N/A | |
Enrolling by invitation |
NCT03672734 -
Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia
|