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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05173688
Other study ID # Propofol and dream
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 30, 2021
Est. completion date May 10, 2022

Study information

Verified date June 2022
Source Shengjing Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. 74% of awakenings from REM sleep resulted in recall of a dream, as compared with only 9% of awakenings from NREM sleep. The association between dreaming and REM sleep was subsequently replicated by many other investigators; typically, around 80% of REM awakenings yield dreams. It became clear over time that there is a good deal of mental activity that occurs during NREM sleep. Typically, it is more thought like, fragmentary, and related to daily concerns than the vivid, hallucinatory, predominantly visual narratives that are most commonly reported from REM sleep. But even this distinction appears not to be absolute. There is now wide acceptance of the view that some dreaming that is indistinguishable from REM sleep dreaming occurs in NREM sleep, most frequently in the sleep-onset period. General anesthesia causes a drug-induced state of unconsciousness and is a non-physiological process that is similar to natural sleep. Patients receiving propofol for maintenance of general anesthesia often report higher incidences of dreaming than patients maintained with volatile anesthetics. One explanation is that propofol and volatile anesthetic have different pharmacological effects in the central nervous system. An alternative explanation is that propofol is associated with more rapid emergence from anesthesia than the older volatile anesthetics, allowing patients to report their dreams before they are forgotten. In order to further verify the hypothesis, the investigators choose gynecological general anesthesia to observe whether the generation of dreams is related to the dose of general anesthesia maintenance .


Recruitment information / eligibility

Status Completed
Enrollment 300
Est. completion date May 10, 2022
Est. primary completion date May 10, 2022
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - between 18 and 70 years - with an ASA physical status of I or II Exclusion Criteria: - presence of sleep disorders - pain syndrome - cardiovascular disease - sleep apnea syndrome - psychosis - history of opioid usage - history of abnormal operation or anesthesia recovery - unwillingness to provide informed consent - a patient with a language communication disorder

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Propofol
The low maintenance dose propofol group was maintained at 4-6 mg/kg/h ;and The high maintenance dose propofol group was maintained at 8-12 mg/kg/h

Locations

Country Name City State
China Shengjing Hospital Shenyang Liaoning

Sponsors (1)

Lead Sponsor Collaborator
Shengjing Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Mean blood pressure (systolic and diastolic) record mean blood pressure during the surgery 5 minutes after entering the operation room
Primary Mean blood pressure (systolic and diastolic) record mean blood pressure during the surgery Anesthesia induction to fall asleep
Primary Mean blood pressure (systolic and diastolic) record mean blood pressure during the surgery at the end of surgery
Primary Mean blood pressure (systolic and diastolic) record mean blood pressure during the surgery Upon awakening from anesthesia
Primary Mean blood pressure (systolic and diastolic) record mean blood pressure during the surgery leaving the operation room
Primary heart rate record heart rate during the surgery entering the operation room
Primary heart rate record heart rate during the surgery Anesthesia induction to fall asleep
Primary heart rate record heart rate during the surgery at the end of surgery
Primary heart rate record heart rate during the surgery Upon awakening from anesthesia
Primary heart rate record heart rate during the surgery leaving the operation room
Primary BIS record BIS during the surgery entering the operation room
Primary BIS record BIS during the surgery Anesthesia induction to fall asleep
Primary BIS record BIS during the surgery at the end of surgery
Primary BIS record BIS during the surgery Upon awakening from anesthesia
Primary BIS record BIS during the surgery leaving the operation room
Primary Total dose of propofol record total dose of propofol at the end of surgery
Primary Dream Dreaming during anesthesia was defined as any experience that was described by the patient as dreaming and was thought by the patient to have occurred between the induction of anesthesia and the first moment of consciousness after anesthesia.27 Awareness was defined as postoperative recall of intraoperative events. All patients who reported dreaming were considered to be "dreamers" for the purpose of the analyses, whether or not they could remember the narrative of the dream. However, only dreaming reports where the narrative was remembered were classified using five-point Likert scales as follows. Emotional content (1 very negative; 5 very positive) ? Memorability (1 can't remember narrative of dream; 5 most memorable ever) ? Visual vividness (1 not at all vivid; 5 most vivid ever) ? Amount of sound (1 no sound; 5 most sound ever) at the end of surgery
Secondary Postoperative adverse effects record postoperative adverse effects 24 hours after surgery
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