General Anesthesia Clinical Trial
Official title:
The Relationship Between the Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and over, which refers to cognitive function changes such as memory decline and attention deficit after anesthesia and surgery. In severe cases, personality changes and social behavior decline may also occur, resulting in irreversible cognitive impairment.Previous studies have suggested that cognitive dysfunction after general anesthesia is linked to a genetic disorder of the body clock.Exosomes are cellular forms of cellular microvesicles containing complex RNA and proteins.Exosomes can mediate the expression of genes in the late transcriptional period of the clock system, and directly or indirectly participate in the negative regulation of rhythm expression of minute control genes, playing an important role in the intercellular circadian rhythm information output pathway.Rhythm disorders in the core biological clock system of urinary exosomes and the clock control genes related to kidney can early indicate circadian rhythm changes in the core biological clock system.The sorting and detection of urinary exosome clock information materials in patients has the advantages of easy access, continuous monitoring, early diagnosis and less damage, making urinary exosome a biomarker for the diagnosis and monitoring of circadian rhythm of a good kidney biological clock system.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04577430 -
Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
|
N/A | |
Completed |
NCT03708692 -
Menstrual Cycle Phases on Recovery and Cognitive Function
|
||
Recruiting |
NCT03422315 -
Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection
|
N/A | |
Completed |
NCT02771067 -
The Utility of Pulse Pressure Variation to Predict the Fluid Responsiveness During Pneumoperitoneum and Reverse-Trendelenburg Position
|
N/A | |
Completed |
NCT05063461 -
Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane
|
N/A | |
Completed |
NCT03294226 -
Comparison of AuraGain With I-gel for Pediatric Patients
|
N/A | |
Not yet recruiting |
NCT03643029 -
The Accuracy of the Performance and Placement Test for Predicting Supraglottic Airway Device (SAD) Position in the Hypopharynx as Confirmed With Video Laryngoscopy
|
N/A | |
Completed |
NCT01945411 -
Assessment of Facial Measurements, the Length of Mouth Corner-mandible Angle and Incisors-mandible Angle, for Determining the Proper Sizes of Oropharyngeal Airway
|
N/A | |
Not yet recruiting |
NCT01678066 -
A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor
|
N/A | |
Completed |
NCT01705743 -
Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG
|
Phase 4 | |
Completed |
NCT00972491 -
The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
|
N/A | |
Completed |
NCT01096212 -
Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia
|
Phase 4 | |
Completed |
NCT00741507 -
Unhealthy Alcohol Drinking and Anesthetic Requirement in Women
|
N/A | |
Completed |
NCT00599066 -
Intraoperative M-Entropy Measurements
|
N/A | |
Completed |
NCT00532402 -
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
|
N/A | |
Completed |
NCT00468494 -
Can Blood Glucose Levels During the Perioperative Period Identify a Population at Risk for Hyperglycemia?
|
N/A | |
Recruiting |
NCT00492453 -
Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy
|
N/A | |
Recruiting |
NCT03745079 -
Correlation Between Core Temperature and Skin Temperature Measured by 3M SpotOn
|
||
Completed |
NCT04094376 -
Comparison of Morning Operation and Evening Operation on Postoperative Sleep Quality and Pain Under General Anesthesia
|
N/A | |
Enrolling by invitation |
NCT03672734 -
Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia
|