General Anesthesia Clinical Trial
Official title:
Predicting Bispectral Index Values by Estimated Effect-site Concentration of Propofol and Remifentanil Displayed on the Target-centered Infusion Pump
The BIS is influenced by multiple parameters, such as age,gender, body weight, height, muscle relaxants, hepatic function, co-administered drugs, surgical stimulation, but is thought to be influenced mainly by propofol and remifentanil infusion dose. As such, the investigators postulate that the BIS value could be predicted by the estimated effects-site concentration of propofol and remifentanil, and try to establish a multiple linear regression model for predicting BIS value.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 2014 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Those undergoing gynecologic or urologic surgery with general anesthesia with total intravenous anesthesia - Adult patients with more than 20 yrs. - American Society of Anesthesiologists Class I or II. Exclusion Criteria: - Those with unstable hemodynamics - Those who can not undergo Bispectral index monitoring - Those with previous history of stroke |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Samsung Medical Center | Seoul |
Lead Sponsor | Collaborator |
---|---|
Samsung Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Bispectral index value | Bispectral index value after anesthetic induction every 10 minutes interval until the end of surgery | every 10 min after anesthetic induction | No |
Secondary | Propofol concentration | estimated propofol effect-site concentration displayed in target-centered infusion pump every 10 minutes interval | every 10 min after anesthetic inducton | No |
Secondary | Remifentanil concentration | estimated remifentanil effect-site concentration displayed in target-centered infusion pump every 10 minutes interval | every 10 minutes after anesthetic induction | No |
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