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NCT00532402 Clinical Trial

Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

General Anesthesia Clinical Trial

Official title:
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas - Compared With Propofol Concentration in Plasma (Before and) After Lung Passage and Neurophysiological Parameters

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00532402
Other study ID # P-A-S-1
Secondary ID
Status Completed
Phase N/A
First received September 18, 2007
Last updated October 29, 2012
Start date September 2007
Est. completion date December 2010

Study information
Verified date October 2012
Source University of Luebeck
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.

Recruitment information / eligibility
Status Completed
Enrollment 16
Est. completion date December 2010
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria:

- Patient destined for general anesthesia

Exclusion Criteria:

- Heart insufficiency NYHA IV

- Allergy to propofol

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Germany Dept. of Anesthesiology , UK-SH, Campus Luebeck Luebeck Schleswig-Holstein
Germany Dept. of Anesthesiology, UK-SH, Campus Luebeck Luebeck Schleswig-Holstein

Sponsors (1)
Lead Sponsor Collaborator
University of Luebeck

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Grossherr M, Hengstenberg A, Meier T, Dibbelt L, Gerlach K, Gehring H. Discontinuous monitoring of propofol concentrations in expired alveolar gas and in arterial and venous plasma during artificial ventilation. Anesthesiology. 2006 Apr;104(4):786-90. — View Citation

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