Memory Clinical Trial
Official title:
Effect of Bilberry (European Blueberries) and Grape Polyphenols on Cognition and Blood Parameters in Normal, Aged Men With Subjective Memory Decline
The purpose of this study is to determine whether dietary intervention with blueberry and grape juice extracts in elderly men with subjective memory problems would raise performance on neuropsychological memory tests and change biomarker of muscle damage and whole blood gene expression profiles.
A number of studies have shown that increased dietary intake of fruits and vegetable
extracts high in antioxidants (e.g., blueberries, strawberries and spinach) can retard and
even reverse age-related decline in brain function and in cognitive and motor performance in
rats. This is the first placebo-controlled human study to evaluate the effect of dietary
intake of fruit polyphenols on neuropsychological test scores and whole blood gene
regulation
Sixty-two non-demented, non-depressed men (age 67-77 years) with subjective memory decline,
were randomly assigned to a blueberry/grape juice- and placebo-group in a 9 week double
blind intervention study. Pre- and post treatment assessment were measured with a
computerised neuropsychological test battery (CANTAB), including tests for motor speed,
visual reaction time, and spatial memory. Dietary habits were registered before intervention
and several clinical biomarkers were measured in plasma/serum before and after the
intervention. Pre- and post intervention-samples for measurement of gene regulation were
also collected
;
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01007682 -
Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression
|
N/A | |
| Completed |
NCT04330677 -
Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin
|
Phase 1 | |
| Active, not recruiting |
NCT04392908 -
Communication Memory of Cancer Diagnosis Within the Pediatric Triangle
|
||
| Recruiting |
NCT04694534 -
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
|
N/A | |
| Completed |
NCT01159652 -
Hypnotic Medications and Memory: Effect of Drug Exposure During the Night
|
Phase 4 | |
| Recruiting |
NCT04598945 -
Acquisition and Retention of Motor Memories in Adults and Typically Developing Children
|
N/A | |
| Terminated |
NCT04021797 -
Autonomic Mechanisms of Sleep-dependent Memory Consolidation
|
N/A | |
| Not yet recruiting |
NCT04103463 -
Interactive Stepping Exercise on Memory
|
N/A | |
| Completed |
NCT04025255 -
The Memory and Cognitive Performance Study
|
N/A | |
| Recruiting |
NCT06351098 -
Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition
|
Early Phase 1 | |
| Completed |
NCT06047899 -
Influence of Luteolin for Two Weeks on Memory in Healthy Subjects
|
N/A | |
| Recruiting |
NCT04402294 -
Individualized Closed Loop TMS for Working Memory Enhancement
|
N/A | |
| Completed |
NCT01126229 -
Resveratrol for Improved Performance in the Elderly
|
Phase 1 | |
| Completed |
NCT00913640 -
Prospective Memory in Parkinson's Disease
|
||
| Completed |
NCT03974399 -
BDNF Levels After Bacopa
|
N/A | |
| Completed |
NCT01143194 -
A Randomized, Placebo-Controlled, Double-Blind, Crossover Study to Evaluate the Effects of Three Doses of the Dietary Supplement oréVida™ on Alertness, Attention and Concentration in Healthy Men and Women
|
Phase 1 | |
| Completed |
NCT00454454 -
Virtual Reality Helmet to Test for Problems With Memory
|
N/A | |
| Completed |
NCT00584324 -
Depth of Anesthesia on Implicit Memory
|
N/A | |
| Completed |
NCT06074172 -
The Effect of Cannabidiol in Learning and Memory of Adults
|
Phase 2 | |
| Completed |
NCT03763409 -
Losartan and Emotional Memory
|
N/A |