Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT00918359
Other study ID # 782-2008-IDF-CTIL
Secondary ID
Status Recruiting
Phase N/A
First received June 10, 2009
Last updated June 28, 2011
Start date May 2009

Study information

Verified date June 2011
Source Medical Corps, Israel Defense Force
Contact Chen Makranz, Dr
Phone 03-7376584
Email chenma@sheba.health.gov.il
Is FDA regulated No
Health authority Israel: Israeli Health Ministry Pharmaceutical Administration
Study type Observational

Clinical Trial Summary

Heat Intolerance (HI) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups. We have demonstrated malfunction of transcriptional pathways in the heat stressed HI phenotype and an altered gene expression profile compared to Heat Tolerant (HT) individuals. Such differences are evident even under normothermic basal/comfort conditions. Heat and exercise challenges during the heat tolerance test (HTT) further emphasize the differences between the groups, particularly during recovery at comfort temperatures. Our results indicate that it may be possible to identify markers of heat intolerance. To achieve this goal, we plan to design a cellular (lymphocyte) HTT experimental model and detect gene expression profiles using customized DNA microarrays and bioinformatic tools (the genes selected will be based on our previous DNA microarray studies). Lymphocyte samples collected from HT and HI individuals under resting/comfort conditions will be examined. Treatments and analyses are designed to reveal HI-associated gene-expression profiles (constitutive or inducible), and thereby find lymphocyte markers to identify individuals predisposed to heat injury. The identification of such subjects could prevent unnecessary loss of life. Notably, the rapidly changing climate in our era increases the number of occupation/age groups in which manifestations of HI will appear.


Recruitment information / eligibility

Status Recruiting
Enrollment 50
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria:

- Experienced heat exhaustion or heat stroke in their past

- Participating in heat tolerance tests (HTT)

Exclusion Criteria:

- Unambiguous result of the HTT

- HTT stop by the subject decision

Study Design

Observational Model: Case-Only, Time Perspective: Prospective


Related Conditions & MeSH terms


Locations

Country Name City State
Israel Heller Institute of Medical Research Ramat Gan

Sponsors (1)

Lead Sponsor Collaborator
Medical Corps, Israel Defense Force

Country where clinical trial is conducted

Israel, 

See also
  Status Clinical Trial Phase
Completed NCT05620043 - Gene Expression Study Between Two Dermal Injectables Hydroxylapatite Semi-permanent Filler N/A
Recruiting NCT05327400 - Expression and Clinical Significance of IGHD in Pancreatic Cancer
Completed NCT04868227 - Scottish Vitamin D Intervention Study N/A
Completed NCT01681394 - Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression N/A
Completed NCT01723410 - Neural and Physiological Responses to Real-World Experiences N/A
Completed NCT04415697 - Identification of Predictive Gene Expression Profile of Sunitinib Response in Metastatic Clear Cell Renal Carcinomas
Recruiting NCT01321112 - Search for Transcriptional Biomarkers in a Conversion Protocol From Calcineurin Inhibitors to Mycophenolate Mofetil N/A
Completed NCT01316731 - MyoGene: Effects of Acute Exercise on (Myokine) Gene Expression in Human Skeletal Muscle N/A
Completed NCT00859196 - Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries Phase 4
Completed NCT01806441 - Impact of a Short-Term High Fat or Low Fat Diet on Intestinal Genes Expression Involved in the Cholesterol and Fatty Acid Metabolism N/A
Recruiting NCT04789057 - Atorvastatin Effect on Reduction of COPD Exacerbations Phase 4
Terminated NCT04737044 - Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects N/A
Active, not recruiting NCT00972972 - Effect of Bilberry (European Blueberries) and Grape Polyphenols on Cognition and Blood Parameters Phase 0
Withdrawn NCT01524523 - Bone Marrow Aspiration Pain Study N/A
Completed NCT01052649 - Gene Expression Monitoring of Mononuclear Cells (MNC) Subpopulations and Immunological Status and Metabolome Defining of Healthy Population N/A