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[18F]MC225 PET to Evaluate Gender Differences in BBB P-gp Function

Gender Clinical Trial

Official title:
The Impact of Gender Differences in P-glycoprotein Function Measured With [18F]MC225 and PET

Clinical Trial Summary

P-gp is one of the main efflux transporters at the blood-brain barrier and is responsible for the transport of a variety of neurotoxic substances, including pharmaceuticals. Multiple studies report gender differences in therapeutic outcomes, toxicity and side effects for many drug agents. P-gp plays an important role in the bio-availability, drug distribution, metabolism and elimination of pharmaceuticals labelled as P-gp substrates (e.g. the majority of antidepressants and antipsychotics). A difference in P-gp function was already reported in hepatic P-gp expression. The aim of the current study is to evaluate the influence of gender on cerebral P-gp function. Outcomes of this study can be of great importance in gender-based prescription of P-gp substrate pharmaceuticals.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05618119
Study type Interventional
Source University Medical Center Groningen
Contact Pascalle Mossel, Msc
Phone +3150 361 6161
Email p.mossel@umcg.nl
Status Not yet recruiting
Phase N/A
Start date January 1, 2023
Completion date January 1, 2025
View Details
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