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Lenvatinib, Pembrolizumab, and Tumor Treating Fields (TTFields) for Second-line Treatment of Glioblastoma

GBM Clinical Trial

Official title:
Lenvatinib, Pembrolizumab, and Tumor Treating Fields (TTFields) for Second-line Treatment of Glioblastoma

Clinical Trial Summary

This will be a prospective, open label, single center, phase I lead-in study of 10 patients to a single arm phase-II study of 37 additional patients to assess the effectiveness of pembrolizumab and lenvatinib combination therapy for recurrent glioblastoma (rGBM) patients wearing TTFields electrodes.

Clinical Trial Description

Male and female patients, 18 years of age or older, with confirmed GBM progressed after first-line treatment. Patients either with or without first-line TTFields alternating field therapy - will be eligible to enroll in the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05973903
Study type Interventional
Source Tel Aviv Medical Center
Contact Deborah T Blumenthal, Prof.
Phone +972-3-6947667
Email dvorab@tlvmc.gov.il
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date January 1, 2024
Completion date October 1, 2027
View Details
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