High Flow Nasal Cannula in Patients Undergoing Gastroscopy

Status Not yet recruiting

Clinical Trial Summary

During gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce modifications to respiratory mechanics, respiratory effort and breathing pattern. High-flow nasal cannula (HFNC) therapy is a mixed air-oxygen supply system able to deliver heated humidified gas up to 60 L/min of flow rate, with an inspiratory oxygen fraction (FiO2) ranging from 21% to 100%. Increasing evidence supports the use of HFNC in several clinical conditions and settings. When compared to standard therapy (ST), HFNC results in enhanced gas exchange and improved comfort. No studies have yet assessed the benefits of HFNC versus ST during and after gastroscopy. We designed this unblinded randomized controlled trial to assess whether HFNC, compared to ST, improves oxygenation at the end of the procedure (primary endpoint). Additional endpoints were: 1) the lowest peripheral saturation of oxygen (SpO2) and the number of oxygen desaturations; 2) the changes of end-expiratory lung impedance and tidal impedance assessed by Electrical Impedance Tomography (EIT); 3) the effects on diaphragm function assessed by ultrasound (DUS).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Gastroscopy

Clinical Trial Details

NCT number	NCT05693298
Study type	Interventional
Source	University Magna Graecia
Contact	Federico Longhini
Phone	+393475395967
Email	longhini.federico@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	February 1, 2023
Completion date	June 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01350050` - Topical Pharyngeal Anesthesia With Articaine for Gastroscopy	Phase 4
Completed	`NCT04292496` - Anastomotic Leak Testing in Gastrectomy	N/A
Completed	`NCT05219136` - Improve the Comfort, Safety and Quality of Upper Endoscopy by a Modified Fasting Protocol	N/A
Completed	`NCT04150237` - Using Simulation to Ensure Basic Competence in Gastroscopy
Completed	`NCT05012527` - Retrospective Review of Gastrointestinal System Endoscopy Procedures
Completed	`NCT05504434` - Performance of a Single-use Gastroscope (aScope Gastro) for Esophagogastroduodenoscopy	N/A
Recruiting	`NCT05965921` - Real-life Prospective Evaluation of Computer-aided Detection (CAD) of Barrett's Neoplasia
Completed	`NCT02576340` - Spasmolytic in Upper Gastrointestinal Endoscopy	Phase 4
Completed	`NCT01154530` - Chlorhexidine Mouthwash and Bacterial Contamination During Endoscopy	N/A
Completed	`NCT05773807` - Effect of Bispectral Index Monitoring (BIS) on Body Movement of Outpatients Undergoing Gastroscopy	N/A
Completed	`NCT04247399` - Simulation-assisted Teaching in Learning Gastroscopy	N/A
Completed	`NCT04682821` - The Research of AI Assistant Gastroscope Training	N/A
Completed	`NCT01151228` - Bedside Ultrasound Assessment of Gastric Content and Volume	N/A
Recruiting	`NCT04641455` - Use of Mucolytic Solution Before Upper Endoscopy	N/A
Not yet recruiting	`NCT06303037` - Effect of Esketamine on 95% Induction Dose of Remimazolam	Phase 4